Quality specifications and the assessment of the biochemical risk of atherosclerosis

Clinica Chimica Acta; International Journal of Clinical Chemistry
N Rifai, G Russell Warnick

Abstract

Coronary heart disease (CHD) is the major cause of death in the western world and biochemical markers have been used to identify those individuals who are at increased risk. Although numerous markers have been considered, only total, low-density lipoprotein (LDL), and high-density lipoprotein cholesterol, triglyceride and C-reactive protein (CRP) have been recommended for assessing CHD risk in routine clinical practice. Specific performance goals have been established for the lipid markers and for the measurement of CRP considering both some significant pre-analytical and analytical issues which could affect the quality of their measurements. The target for quality specifications for LDL-C with the reference method are CV < or =4% and bias < or =4%. Regarding the measurement of CRP, total imprecision should be <10% across the linear range of the assay and the analytical sensitivity may allow a reliable measurement at values lower than 0.3 mg/l. Although national guidelines do exist for LDL-C measurement, additional studies are needed to better characterize the performances of routine methods. As more data are available for CRP, guidelines for its measurement will be soon developed.

References

Dec 1, 1992·The British Journal of Oral & Maxillofacial Surgery·P P RobinsonD A Coppins
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J V CastellP C Heinrich
Jul 1, 1993·Annals of Clinical Biochemistry·G H Clark, C G Fraser
Sep 15, 1998·The Journal of Laboratory and Clinical Medicine·M OkadaK Inano
Jun 30, 2001·The New England Journal of Medicine·P M RidkerUNKNOWN Air Force/Texas Coronary Atherosclerosis Prevention Study Investigators
Sep 26, 2002·Annals of Clinical Biochemistry·A ElfatihR Gama
Jul 26, 2003·Annals of Clinical Biochemistry·Snjezana Rothkrantz-KosMarja P van Dieijen-Visser
Oct 2, 2003·Vascular Medicine·Peter Leong-Sit, Sonia S Anand
Sep 29, 2007·Clinical Chemistry·Kazuhito MiyauchiTaku Yamamura
Jul 31, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·M E AshmaigG R Warnick

❮ Previous
Next ❯

Citations

May 7, 2010·European Journal of Applied Physiology·Lázaro Alessandro S NunesDenise Vaz de Macedo
Mar 28, 2007·Journal of Clinical Laboratory Analysis·Ali Riza SişmanPinar Tuncel
Jul 4, 2006·Journal of the American College of Cardiology·Allan S JaffeFred S Apple
Apr 19, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Mario Plebani

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.