Quality specifications for biochemical markers of myocardial injury

Clinica Chimica Acta; International Journal of Clinical Chemistry
M ZaninottoM Plebani

Abstract

The current approach to the diagnosis and monitoring of myocardial damage, recognizes to biochemical markers, and in particular to troponins, a key role being well demonstrated that all elevated values were associated with a worsened prognosis. In 2001, the IFCC Committee on Standardization of Markers of Cardiac Damage published guidelines addressing the quality specifications for troponin assays in order to guarantee an analytical performance satisfying medical requirements and to standardize the quality of commercial methods. We describe how the application of quality specifications may be useful in daily practice, in order to provide advice to clinicians in the investigations of complex clinical cases of patients suffering from myocardial damage. The samples from three patients (cases 1-3) admitted to the hospital with symptoms suggestive of cardiac disease, showing high troponin I (cTnI) values not correlated with clinical condition, were investigated in order to verify the accuracy of the laboratory data. The standard of quality specifications related to assay specificity, imprecision and interferences were evaluated using different platforms for cTnI assays, carrying out imprecision profile and specific studies on more co...Continue Reading

Citations

Oct 13, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Sara AltinierMario Plebani
Mar 15, 2014·Biochemia Medica·Raffick A R Bowen, Alan T Remaley
Mar 15, 2011·The American Journal of Medicine·Matthew W MartinezAllan S Jaffe
Oct 14, 2009·Clinical Biochemistry·Raffick A R BowenAlan T Remaley
May 28, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yusheng ZhuNancy Drayton
Dec 26, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·C BiondaA Charrié
Sep 18, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe LippiGianfranco Cervellin
Feb 7, 2018·International Journal of Laboratory Hematology·A MolinaA Merino

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