Quality specifications in EQA schemes: from theory to practice

Clinica Chimica Acta; International Journal of Clinical Chemistry
Laura SciacovelliMario Plebani

Abstract

External quality assessment (EQA) is a tool for quality management in clinical laboratories and its main objectives are assessment of participants and methods performance, training and advice. This paper describes the quality specifications used in EQA schemes of the Centre of Biomedical Research (CRB), in order to design schemes that can assess laboratory reliability performances, meet the changing needs and quality recommendations. Quality specifications for control materials, statistical procedures and goals to assess laboratory performance have been applied and introduced in EQA schemes managed by CRB. The application of well-defined quality specifications has demonstrated effective. In particular, we report results on alkaline phosphatase and cholesterol obtained using commercial control materials and human serum controls, in two different EQA surveys; the inter-laboratory variability (CVinter%) for troponin I analysed with a diagnostic system and assigned values of CK-MB mass obtained using four different diagnostic systems; the percentage of acceptable performances obtained by means of the application of goals based on clinical criteria, biological variation, state-of-the-art and used for EQA schemes, and referring to so...Continue Reading

References

Mar 25, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Plebani
Mar 25, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Waise
Feb 10, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·J O Westgard
Feb 10, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·C G Fraser
Jul 5, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·J C Libeer
Jul 5, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·L SciacovelliM Plebani

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Citations

Nov 20, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·David BurnettJames Westgard
Apr 8, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Fengfeng KangZhiguo Wang
Jun 21, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Mario Plebani
Oct 20, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Sandra SecchieroMario Plebani
Oct 5, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qi ZhouZhiguo Wang
May 26, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Laura SciacovelliMario Plebani
Mar 30, 2010·Clinical Chemistry·George G Klee
Dec 13, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·John D OlsonIsobel Walker
Jul 1, 2012·Indian Journal of Clinical Biochemistry : IJCB·Rixin Jamtsho, Wilairat Nuchpramool
Jun 9, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Graham R D JonesUNKNOWN EFLM Task Finish Group – Analytical Performance Specifications for EQAS (TFG-APSEQA)
Dec 15, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sandra SecchieroMario Plebani
Feb 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Sandra SecchieroMario Plebani
May 10, 2021·Clinical Biochemistry·Tony Badrick

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