Quality specifications in thyroid diseases

Clinica Chimica Acta; International Journal of Clinical Chemistry
Alan H B Wu

Abstract

Laboratory tests to support the diagnosis and management of thyroid diseases have undergone significant changes with the introduction of highly sensitive assays for thyroid stimulating hormone (TSH) and free T4 and T3 concentrations in plasma. Given the importance of these measurements, quality specifications are needed to ensure accurate results. Goals for precision and accuracy are available based on known intraindividual and interindividual biological variation. Results of external quality assurance (EQA) schemes are sufficient to document precision goals but survey materials are not commutable for use in determining bias or detect the presence of unusual antibodies on a case-by-case basis. Because TSH concentrations are inversely related to free T4, this physiologic relationship can be exploited for quality assurance purposes. Significant discordance between this relationship can be caused by subclinical and potentially unrecognized disease, dysequilibrium caused by recent therapy, the presence of abnormal binding proteins or protein binding competitor drugs, and antibody interferences such as human antimouse antibody (HAMA) or rheumatoid factor. A mechanism to automatically track discordances for subsequent follow and inve...Continue Reading

References

Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·C A SpencerJ T Nicoloff
Feb 18, 1998·JAMA : the Journal of the American Medical Association·T M StullC L Collins
Apr 27, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Landau-LevineA M Gronowski
Mar 11, 2003·Thyroid : Official Journal of the American Thyroid Association·Zubair BalochUNKNOWN Guidelines Committee, National Academy of Clinical Biochemistry

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Citations

Aug 14, 2010·International Journal of Analytical Chemistry·Rochelle E TractenbergSteven J Soldin
Feb 7, 2018·International Journal of Laboratory Hematology·A MolinaA Merino
Jul 16, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Steven J SoldinOffie P Soldin

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