Quality use of medicines: a new method of combining antibiotic consumption and sensitivity data--application in a Russian hospital

Pharmacoepidemiology and Drug Safety
Ksenia GoryachkinaU Bergman

Abstract

Antibiotic use and resistance is subject of great concern. There is a need for internationally comparable and locally useful data collection and reporting. We developed a new method to combine and present data on antibiotic use and resistance in a figure in a Russian 1300 bed-hospital. We applied World Health Organization (WHO) Anatomic Therapeutic Chemical (ATC) classification/defined daily doses (DDD) analysis on antibacterials for systemic use (ATC: J01) delivered by the pharmacy for the years 2003-2005. Microbial resistance data were presented within the range of drugs accounting for 90% of the volume in DDD, i.e. drug utilisation 90% (DU90%). From the DU90% profile the following was seen: in 2003, 12 of 25 drugs accounted for 90% of the volume. For six of the most commonly used antibiotics, including the two cheapest (gentamicin, ampicillin), a significant number of the strains tested were resistant. For the remaining antibiotics no resistance data were available. These data were discussed in early 2004. A general decrease of antibiotic use and resistance was seen in 2005 (by 57% from 15.5 to 8.8 DDD/100 bed days) with a concomitant decrease in expenditures (by 64%) and a shift to more potent antibiotics. The created profi...Continue Reading

References

Apr 1, 1995·Emerging Infectious Diseases·T F O'Brien, J M Stelling
Jun 17, 1998·European Journal of Clinical Pharmacology·U BergmanF Sjöqvist
Jun 19, 2001·Lancet·O CarsA Melander
Oct 24, 2001·International Journal of Antimicrobial Agents·L StratchounskiV Semenov
Nov 22, 2001·The Journal of Hospital Infection·L S StratchounskiR S Kozlov
Jan 5, 2002·European Journal of Epidemiology·V Vlahović-PalcevskiL Betica-Radić
Feb 2, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J GulbinovicU Bergman
Dec 4, 2002·The Journal of Antimicrobial Chemotherapy·Alberto VaccheriNicola Montanaro
Apr 17, 2003·European Journal of Clinical Pharmacology·Marit RønningRobert Vander Stichele
Jul 2, 2003·Annals of Internal Medicine·Gilad J Kuperman, Richard F Gibson
Apr 10, 2004·Pharmacoepidemiology and Drug Safety·Goran PalcevskiL Averchenkova
Jul 23, 2004·Pharmacoepidemiology and Drug Safety·Ulf BergmanOrjan Ericsson
May 16, 2006·The Journal of Antimicrobial Chemotherapy·R H Vander SticheleUNKNOWN European Survaillance of Antibiotic Comsuption (ESAC) Project Group
Mar 30, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V Vlahović-PalcevskiU Bergman
Jul 1, 2006·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·J StruweU Bergman

❮ Previous
Next ❯

Citations

May 13, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Radmila Veliĉković-RadovanovićGordana Randelović
Feb 9, 2011·Journal of Clinical Pharmacy and Therapeutics·R Velickovic-RadovanovicR Mitic
Feb 24, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Roni BittermanMical Paul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

European Journal of Clinical Pharmacology
V Vlahovic-PalcevskiG Palcevski
Médecine et maladies infectieuses
Dominique L Monnet, J M López-Lozano
International Journal of Clinical Pharmacology and Therapeutics
V Vlahovic-PalcevskiU Bergman
International Journal of Antimicrobial Agents
I M Gould
© 2021 Meta ULC. All rights reserved