PMID: 7536028Jan 1, 1995Paper

Quality versus quantity of life in the treatment of patients with advanced small-cell lung cancer? A randomized phase III comparison of weekly carboplatin and teniposide versus cisplatin, adriamycin, etoposide alternating with cyclophosphamide, methotrexate, vincristine and lomustine. Swiss Group for Clinical Cancer Research (SAKK)

Annals of Oncology : Official Journal of the European Society for Medical Oncology
R JossC Ludwig

Abstract

Based on a promising pilot study with weekly carboplatin and teniposide (CBDCA/VM) the Swiss Group for Clinical Cancer Research (SAKK) performed a randomised phase III trial in patients with extensive-disease small-cell lung cancer aimed at the development of an effective palliative treatment with low subjective toxicity. From September 1989 to September 1991 patients were randomised to a weekly regimen of CBDCA/VM or to our 'standard chemotherapy' of cisplatin, adriamycin and etoposide alternating with cyclophosphamide, methotrexate, vincristine and lomustine (PAV-CyMOC). The trial was closed before the planned accrual of 140 evaluable patients due to a significant survival difference shown by an interim analysis. Of the 61 patients 59 were eligible and included in the final analysis. The results achieved with the PAV-CyMOC regimen were significantly better than those observed in patients treated with weekly CBDCA/VM (remission rate of 65% vs. 29%; p = 0.006). The median survival of patients treated with the PAV-CyMOC combination was significantly longer than that of patients receiving weekly CBDCA/VM (260 days vs. 147 days; p = 0.0035). The 1-year survival rate was 30% in the PAV-CyMOC arm compared to 4% in the CBDCA/VM-treat...Continue Reading

Citations

Apr 27, 2004·Cancer·Stephen T SonisUNKNOWN International Society for Oral Oncology
Apr 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio RossiSiow-Ming Lee
Aug 2, 2013·Expert Opinion on Pharmacotherapy·Assunta SgambatoCesare Gridelli
Nov 28, 2013·The Cochrane Database of Systematic Reviews·Marta Pelayo AlvarezXavier Bonfill Cosp
Sep 22, 2015·The Cancer Journal·Mehmet Altan, Anne C Chiang
Feb 12, 2021·Prostate Cancer and Prostatic Diseases·Jacob E BerchuckAna Aparicio

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