Quantal analysis and synaptic anatomy--integrating two views of hippocampal plasticity

Trends in Neurosciences
J E Lisman, K M Harris

Abstract

The excitatory synapses onto CA1 pyramidal cells have become a model system for understanding the activity-dependent changes in synapses that underlie learning and memory. Here we examine physiological and anatomical results that are relevant to understanding the mechanisms of synaptic transmission and plasticity at these synapses. Three main points are discussed. First, quantal analysis indicates a large heterogeneity of postsynaptic efficacies for different synapses on the same cell. Reconstructions from electron microscopy show that synapse size is also highly heterogeneous. Reasons for suspecting a relationship between synaptic size and efficacy are discussed. Second, physiological evidence indicates that the changes during long-term potentiation are both pre- and postsynaptic. Similarly, several lines of anatomical evidence suggest that plasticity affects the structure of both the pre- and postsynaptic elements. The detailed registration of structures across the synapse and the physical linkage between pre- and postsynaptic elements suggest a 'structural unit hypothesis' for coordinating pre- and postsynaptic modifications. Third, quantal analysis indicates that stimulation of a single axon can release multiple quanta. Ana...Continue Reading

References

Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Oct 1, 1994·Pflügers Archiv : European journal of physiology·C LüscherH R Lüscher
Oct 1, 1995·Pflügers Archiv : European journal of physiology·K VogtJ Streit
Dec 1, 1996·Journal of Neurocytology·R E Schmidt
May 23, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·James P KebleshHuangui Xiong
Jan 6, 2010·Molecular Neurobiology·Xiao-bin Wang, Qiang Zhou
Nov 1, 1995·Neuropharmacology·G Liu, R W Tsien
Sep 1, 1995·Brain Research. Brain Research Reviews·J H Medina, I Izquierdo
Aug 1, 1995·Journal of Neuroscience Methods·D A Rusakov, M G Stewart
Oct 1, 1994·Trends in Neurosciences·J E Lisman
Dec 1, 1994·Trends in Neurosciences·I ModyI Soltesz
Jun 1, 1995·Trends in Neurosciences·F Edwards
Feb 1, 1994·Neuroscience·J P Pierce, G R Lewin
Nov 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A A KhanV Bijlani
Jan 1, 1994·Journal of Physiology, Paris·J E Lisman, K M Harris
Jun 1, 1994·Current Opinion in Neurobiology·J M Bekkers
Jun 1, 1994·Current Opinion in Neurobiology·P Jonas, N Spruston
Mar 12, 2004·Progress in Neurobiology·P V Nguyen, N H Woo
Aug 9, 2003·Neuropharmacology·L L Voronin, Enrico Cherubini
Jul 9, 2002·Brain Research. Developmental Brain Research·Bünyami UnalSüleyman Kaplan
Mar 16, 2000·Trends in Neurosciences·S Halpain
Mar 14, 1998·Trends in Neurosciences·B WalmsleyR E Fyffe
Nov 19, 1997·Neurochemistry International·M Knipper, R J Rylett
Oct 16, 2008·Nature Reviews. Neuroscience·Geoffrey A Kerchner, R A Nicoll
Aug 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ami Citri, Robert C Malenka
Oct 23, 2002·Journal of Neurochemistry·Huei-Hsuan JanYen-Chung Chang
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hyun Jae PiJ E Lisman
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·R MalinowJ E Lisman

Citations

Jul 1, 1978·The Journal of Cell Biology·R S Cohen, P Siekevitz
Jul 10, 1992·Cell·M J Ferns, Z W Hall
Oct 1, 1992·Current Opinion in Cell Biology·U J McMahanG Escher
Nov 27, 1992·Science·J D ClementsG L Westbrook
Jan 1, 1991·Hippocampus·G W Van HoesenA R Damasio
Mar 28, 1991·Nature·F Edwards
Jan 15, 1991·The Journal of Comparative Neurology·N Tamamaki, Y Nojyo
Aug 23, 1990·Nature·J M Bekkers, C F Stevens
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J M BekkersC F Stevens
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E Lisman, M A Goldring
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G E Fagg, A Matus
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER

Related Concepts

Synaptic Transmission
Neuronal Plasticity
Electron Microscopy, Diagnostic
Axon
Synapses
Electron Microscopy
Pyramidal Cells
Structure of Subiculum Hippocampi
Genetic Linkage
Long-Term Potentiation

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.