'Quantal' calcium release operated by membrane voltage in frog skeletal muscle

The Journal of Physiology
G PizarroE Ríos

Abstract

1. Ca2+ transients and Ca2+ release flux were determined optically in cut skeletal muscle fibres under voltage clamp. 'Decay' of release during a depolarizing pulse was defined as the difference between the peak value of release and the much lower steady level reached after about 100 ms of depolarization. Using a double-pulse protocol, the inactivating effect of release was measured by 'suppression', the difference between the peak values of release in the test pulse, in the absence and presence of a conditioning pulse that closely preceded the test pulse. 2. The relationship between decay and suppression was found to follow two simple arithmetic rules. Whenever the conditioning depolarization was less than or equal to the test depolarization, decay in the conditioning release was approximately equal to suppression of the test release. Whenever the conditioning depolarization was greater than that of the test, suppression was complete, i.e. test release was reduced to a function that increased monotonically to a steady level. The steady level was the same with or without conditioning. 3. These arithmetic rules suggest that inactivation of Ca2+ release channels is strictly and fatally linked to their activation. More than a stri...Continue Reading

References

Aug 1, 1992·Biophysical Journal·M D Stern
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T Meyer, L Stryer
Nov 1, 1988·The Journal of Physiology·M F Schneider, B J Simon
Apr 1, 1986·The Journal of Physiology·W MelzerG Szucs
Feb 1, 1994·Quarterly Reviews of Biophysics·F J Sigworth
Feb 1, 1994·Current Biology : CB·M Bootman
Jan 1, 1994·Annual Review of Physiology·M F Schneider
Sep 1, 1993·The Journal of General Physiology·A González, E Ríos
Jan 28, 1993·Nature·M J Berridge
Jan 1, 1996·The Journal of General Physiology·N ShirokovaE Ríos
Jun 1, 1996·The Journal of Physiology·N Shirokova, E Ríos

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Citations

Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·A GonzálezE Ríos
Oct 6, 1997·The Journal of General Physiology·M D SternE Ríos
Mar 3, 1999·The Journal of General Physiology·N ShirokovaH Cheng
Dec 1, 2000·The Journal of General Physiology·M FillS Györke
Sep 22, 2015·Molecular Reproduction and Development·Souvik DeyDebdas Bhattacharyya
May 17, 2008·The Journal of Physiology·Tenpei Akita, Kenji Kuba
Nov 4, 2000·The Journal of Physiology·P SzentesiL Csernoch
Nov 5, 2002·Biophysical Journal·Juliana RengifoEduardo Ríos
Oct 17, 2008·Physiological Reviews·Heping Cheng, W J Lederer
Jun 28, 2016·Journal of Muscle Research and Cell Motility·J Fernando Olivera, Gonzalo Pizarro
Jun 13, 2001·American Journal of Physiology. Cell Physiology·G D LambN Ikemoto
Sep 25, 2002·Physiological Reviews·Michael Fill, Julio A Copello
Jan 1, 1997·Annual Review of Biophysics and Biomolecular Structure·E Ríos, M D Stern

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