PMID: 9434922Jan 22, 1998Paper

Quantification and predictors of plasma volume expansion from mannitol treatment

Intensive Care Medicine
P M AmbühlR Krapf

Abstract

To determine the effects of acute hypertonic mannitol infusion on intravascular volume expansion and to identify potential predictors of hypervolemia. Measurements of plasma volume and volume regulatory hormones were performed in healthy volunteers before and over 90 min after acute infusion of 20% mannitol solution in a therapeutic dose of 0.5 g/kg body weight, equalling an average infusion volume of 180 ml. Clinical research unit in an 800-bed teaching hospital in the eastern part of Switzerland. Eight normal male volunteers. Baseline plasma volume was determined by the indocyanine green dye dilution technique. Serial plasma protein measurements were performed after mannitol infusion to calculate intravascular volume changes. Mannitol administration resulted in a plasma expansion that persisted for more than 90 min and peaked at 112% of the baseline plasma volume 15 min after infusion. Concomitantly, an increase in systolic blood pressure and a fall in plasma sodium concentration occurred. Pharmacokinetic analyses of mannitol distribution and elimination revealed a close relation between plasma volume expansion and mannitol serum concentrations. While renin activity and aldosterone concentrations were suppressed proportionall...Continue Reading

References

Jan 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B R KurnikP B Kurnik
May 1, 1990·Medicine·H R DormanP Cadnapaphornchai
Jul 1, 1990·The Journal of Clinical Endocrinology and Metabolism·B F UretskyP S Reddy
Jan 1, 1987·Renal Physiology·F Lang
Sep 1, 1968·Life Sciences·E C Bradley, J W Barr
Oct 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Bartels, M Cikes
Jan 1, 1993·The Annals of Pharmacotherapy·G M RabetoyC F Hostettler
Jun 1, 1928·The Journal of Clinical Investigation·W O ThompsonM E Dailey

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Citations

Jun 20, 2008·Neurocritical Care·Salah G KeyrouzMichael N Diringer
Sep 11, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Hendrik GraefeLeif Dibbelt
Apr 3, 2007·The Journal of Infection·Maciej Michał KowalikHanna Trocha
Jan 31, 2002·Anesthesiology·Kokila ThenuwaraJohnny E Brian
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T F LeeL C Wang
Oct 23, 2019·Journal of Veterinary Emergency and Critical Care·Maëlle F ClabotsMarcel Aumann

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