Quantification and simulation of layer-specific mitral valve interstitial cells deformation under physiological loading

Journal of Theoretical Biology
Chung-Hao LeeMichael S Sacks

Abstract

Within each of the four layers of mitral valve (MV) leaflet tissues there resides a heterogeneous population of interstitial cells that maintain the structural integrity of the MV tissue via protein biosynthesis and enzymatic degradation. There is increasing evidence that tissue stress-induced MV interstitial cell (MVIC) deformations can have deleterious effects on their biosynthetic states that are potentially related to the reduction of tissue-level maintenance and to subsequent organ-level failure. To better understand the interrelationships between tissue-level loading and cellular responses, we developed the following integrated experimental-computational approach. Since in vivo cellular deformations are not directly measurable, we quantified the in-situ layer-specific MVIC deformations for each of the four layers under a controlled biaxial tension loading device coupled to multi-photon microscopy. Next, we explored the interrelationship between the MVIC stiffness and deformation to layer-specific tissue mechanical and structural properties using a macro-micro finite element computational model. Experimental results indicated that the MVICs in the fibrosa and ventricularis layers deformed significantly more than those in t...Continue Reading

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Citations

Oct 10, 2015·Biomechanics and Modeling in Mechanobiology·Ankush Aggarwal, Michael S Sacks
May 8, 2015·Biomechanics and Modeling in Mechanobiology·Chung-Hao LeeMichael S Sacks
Jun 1, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Frederick J Schoen, Avrum I Gotlieb
Jun 28, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Antonio D'AmoreMichael S Sacks
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Sep 10, 2016·Tissue Engineering. Part a·Christopher DebordeAgneta Simionescu
Dec 10, 2016·International Journal for Numerical Methods in Biomedical Engineering·Hao GaoXiaoyu Luo
Dec 21, 2016·Annals of Biomedical Engineering·Amir H KhalighiMichael S Sacks
Jan 10, 2018·Frontiers in Cardiovascular Medicine·Leah A Pagnozzi, Jonathan T Butcher
Jun 9, 2018·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Emily Earl, Hadi Mohammadi
Aug 5, 2017·International Journal for Numerical Methods in Biomedical Engineering·Andrew DrachMichael S Sacks
Aug 23, 2018·International Journal for Numerical Methods in Biomedical Engineering·Bruno V RegoMichael S Sacks
Apr 21, 2019·Journal of Biomechanical Engineering·Michael SacksJoseph H Gorman Iii
May 18, 2018·Cellular and Molecular Bioengineering·Salma AyoubMichael S Sacks
Dec 9, 2016·Journal of the Royal Society, Interface·Bruno V RegoMichael S Sacks
Apr 22, 2017·Biomechanics and Modeling in Mechanobiology·Chung-Hao LeeMichael S Sacks
Dec 20, 2020·Journal of Cardiovascular Development and Disease·Karthik M KodigepalliJoy Lincoln
Feb 3, 2021·Cardiovascular Engineering and Technology·Daniel P Howsmon, Michael S Sacks
Jul 29, 2017·Medical Engineering & Physics·Hao GaoXiaoyu Luo
Apr 2, 2021·Biomechanics and Modeling in Mechanobiology·G RossiniE Votta

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