Quantification and stability of salbutamol in human urine

Journal of Separation Science
G Forsdahl, Günter Gmeiner

Abstract

A sensitive method for the quantification of free salbutamol in human urine is described. Sample clean up is performed using SPE on a mixed phase extraction column. Derivatisation is performed with N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA) and the extract is analysed by GC-MS. The method was found to be suitable for use in the doping field, where a cut-off limit of 1 microg salbutamol/mL urine is set by the International Olympic Committee (IOC) and approved by the World Anti-Doping Agency (WADA). Above that value a doping violation occurs. In addition, the stability of salbutamol in human urine has been evaluated.

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Citations

Apr 13, 2007·Analytical and Bioanalytical Chemistry·Frank T Peters
May 13, 2011·Analytical and Bioanalytical Chemistry·Lindsey G Mackay, Rymantas Kazlauskas
May 16, 2009·Journal of Pharmaceutical and Biomedical Analysis·S H R A Mazhar, H Chrystyn
Dec 20, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jianli ZhangMoutian Wu
Dec 7, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Rebecca L CordellPaul S Monks

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