Quantification and toxicity of group A streptococcal pyrogenic exotoxins in an animal model of toxic shock syndrome-like illness.

Journal of Clinical Microbiology
P K Lee, P M Schlievert

Abstract

Toxic shock-like syndrome isolates of group A streptococci were evaluated for production of pyrogenic exotoxins (also called SPEs, scarlet fever toxins, and erythrogenic toxins). The isolates were consecutively obtained during 1987 and 1988. Of these isolates, 23 of 26 made SPE type A, 10 of 26 made SPE B, and 8 of 26 made SPE C. SPE A was produced in significantly greater amounts than SPEs B and C (3.2 micrograms/ml of culture fluid compared with 0.7 and 0.6 microgram/ml, respectively). SPE A, administered in miniosmotic pumps implanted subcutaneously in rabbits, was significantly more toxic than SPE C; seven of eight rabbits succumbed after challenge with 150 or 300 micrograms of SPE A, compared with one of six after challenge with SPE C.

References

Nov 1, 1979·Infection and Immunity·P M SchlievertD W Watson
May 1, 1977·Infection and Immunity·P M SchlievertD W Watson
May 1, 1978·Infection and Immunity·E L BarsumianD W Watson
Nov 1, 1979·The Journal of Infectious Diseases·P M SchlievertD W Watson
Aug 1, 1987·Molecular & General Genetics : MGG·G A Bohach, P M Schlievert
Sep 1, 1988·Infection and Immunity·S C Goshorn, P M Schlievert
Jul 16, 1987·The New England Journal of Medicine·L A ConeG S Tomory
Jan 1, 1988·Journal of Bacteriology·M J Betley, J J Mekalanos
Jan 1, 1984·Molecular & General Genetics : MGG·L P Johnson, P M Schlievert
Feb 1, 1983·The Journal of Infectious Diseases·P M Schlievert, D A Blomster
Jan 1, 1955·The Journal of Infectious Diseases·J H SCHWABW J CROMARTIE

❮ Previous
Next ❯

Citations

Jul 5, 2013·Clinical Microbiology Reviews·Adam R SpauldingPatrick M Schlievert
May 4, 2011·The FEBS Journal·Amanda J Brosnahan, Patrick M Schlievert
May 17, 1990·Klinische Wochenschrift·C LerschM Classen
Apr 24, 2003·Antimicrobial Agents and Chemotherapy·Elizabeth A CoyleMichael J Rybak
Sep 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G B CherchiG Orefici
Nov 1, 1995·Journal of Clinical Immunology·P M SchlievertY I Chi
Jun 1, 1992·Immunological Reviews·J AnderssonU Andersson
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda J BrosnahanPatrick M Schlievert
Jun 20, 2002·The Journal of Pediatrics·Donald Y M LeungPatrick M Schlievert
May 8, 2021·Royal Society Open Science·Sowmya Ajay Castro, Helge C Dorfmueller
Mar 1, 1991·Infection and Immunity·B A LeonardP M Schlievert
Nov 18, 2008·Biochemistry·Amanda J BrosnahanPatrick M Schlievert
Jan 11, 2000·Clinical Microbiology Reviews·M M DingesP M Schlievert
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
Dec 1, 1991·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·H KnöllW Köhler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.