Quantification and visualization of charged particle range variations

International Journal of Radiation Oncology, Biology, Physics
Shinichiro Mori, George T Y Chen

Abstract

Range variations during respiration affect the penetration of charged particle beams and can result in beam overshoot or undershoot to the target. We have developed analysis tools to quantify the water equivalent pathlength (WEL) variations resulting from respiration (WEL analyzer, Aqualyzer), as well as a data explorer to view WEL variations interactively. The metrics to characterize and quantify penetration of a charged particle beam during respiration were calculated semiautomatically. The analysis involved the generation of images that (1) encode the radiologic pathlength across a beam's eye view image during the respiratory phase, (2) display the variation of the radiologic pathlength relative to a reference respiratory phase, (3) display isopenetration as a function of breathing, and (4) show range fluctuation images for a compensating bolus when applied to four-dimensional computed tomography. Additional quantities relevant to the analysis of charged particle beams in a breathing patient that are calculated include the beam overshoot volume and beam overshoot distance. These quantities are calculated as a function of time, gantry angle, and position. The software was applied to test cases to illustrate its utility in the...Continue Reading

References

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Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Martijn EngelsmanHanne M Kooy

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Citations

Feb 20, 2013·Radiological Physics and Technology·Shinichiro MoriAntje-Christin Knopf
May 3, 2013·Medical Physics·Joey P CheungLei Dong
Sep 8, 2010·Radiological Physics and Technology·Shinichiro MoriMasayuki Baba
Jun 2, 2012·International Journal of Radiation Oncology, Biology, Physics·Sebastian HildChristoph Bert
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Michael D ChuongSteven H Lin
May 3, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shinichiro MoriShigeo Yasuda
May 18, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Shinichiro MoriNaoyoshi Yamamoto
May 8, 2009·Physics in Medicine and Biology·Motoki KumagaiMasayuki Baba
Aug 20, 2016·Reports on Progress in Physics·Marco Durante, Harald Paganetti
Jul 22, 2011·Physics in Medicine and Biology·C Bert, M Durante
Apr 3, 2015·Radiological Physics and Technology·Shinichiro MoriKentaro Miki

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