Abstract
Nanoimprinting lithography (NIL) is a manufacturing process that can produce macroscale surface areas with nanoscale features. In this paper, this technique is used to solve three fundamental issues for the application of localized surface plasmonic resonance (LSPR) in practical clinical measurements: assay sensitivity, chip-to-chip variance, and the ability to perform assays in human serum. Using NIL, arrays of 140 nm square features were fabricated on a sensing area of 1.5 mm x 1.5 mm with low cost. The high reproducibility of NIL allowed for the use of a one-chip, one-measurement approach with 12 individually manufactured surfaces with minimal chip-to-chip variations. To better approximate a real world setting, all chips were modified with a biocompatible, multi-component monolayer and inter-chip variability was assessed by measuring a bioanalyte standard (2.5-75 ng/ml) in the presence of a complex biofluid, human serum. In this setting, nanoimprinted LSPR chips were able to provide sufficient characteristics for a 'low-tech' approach to laboratory-based bioanalyte measurement, including: 1) sufficient size to interface with a common laboratory light source and detector without the need for a microscope, 2) high sensitivity ...Continue Reading
References
Jun 24, 2000·JAMA : the Journal of the American Medical Association·C P CannonA J Tiefenbrunn
Dec 8, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·G Bernardi
Feb 15, 2001·Physical Review Letters·L Martín-MorenoT W Ebbesen
Apr 14, 2005·Chemical Reviews·Byron D GatesGeorge M Whitesides
Oct 4, 2005·Methods : a Companion to Methods in Enzymology·P R H StarkD N Larson
Jun 6, 2006·Journal of the American College of Cardiology·Robert L McNamaraUNKNOWN NRMI Investigators
Jul 1, 2006·Analytical Chemistry·Andreas B DahlinFredrik Höök
Nov 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Matthew E StewartJohn A Rogers
Nov 9, 2007·Annual Review of Physical Chemistry·James V CoeKenneth R Rodriguez
Feb 22, 2008·Analytical Chemistry·John C SharpeRichard J Blaikie
Mar 1, 2008·Analytical Chemistry·Jin JiDale N Larson
Apr 11, 2008·Nature·Haitao Liu, Philippe Lalanne
Sep 11, 2008·Analytical Biochemistry·Oded NahsholTsafrir Bravman
Apr 2, 2010·Analytical Chemistry·Ludovic S LiveJean-François Masson
Jul 31, 2010·Nanoscale Research Letters·Gansheng XiangXiaodong Zhou
Aug 12, 2010·Nano Letters·Jiun-Chan YangTeri W Odom
Dec 2, 2010·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Haitao Liu, Philippe Lalanne
Mar 26, 2011·Lancet·Martin ThanA Mark Richards
Sep 9, 2011·Lab on a Chip·Tsung-Yao ChangHatice Altug
Nov 22, 2011·Biosensors & Bioelectronics·Longhua Guo, Dong-Hwan Kim
Dec 14, 2011·Advances in Colloid and Interface Science·Abhijit BiswasFranz Faupel
Jan 13, 2012·Analytical Chemistry·Hyungsoon ImSang-Hyun Oh
Jan 31, 2012·Analytical Chemistry·Kohei NakamotoOsamu Niwa
May 15, 2012·Journal of the American College of Cardiology·Martin ThanA Mark Richards
Mar 15, 2013·Nano Letters·Markus SchwindIgor Zorić
Mar 16, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Chiara Valsecchi, Alexandre G Brolo
May 7, 2013·Lab on a Chip·Ten It WongXiaodong Zhou
Sep 11, 2013·Analytical Chemistry·Maniraj BhagawatiJacob Piehler
Oct 17, 2014·Optics Express·En-Hung LinPei-Kuen Wei