Quantification of antiangiogenic and antivascular drug activity by kinetic analysis of DCE-MRI data

Clinical Pharmacology and Therapeutics
G Z Ferl, R E Port

Abstract

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to quantify the response of tumors to vascular targeting agents. Tumor response is frequently assessed using mathematical models that describe the distribution of contrast agents over time as a function of fundamental characteristics of vascular physiology. Generally, mathematical models of biological systems are abstractions that attempt to retain fundamental physiologic characteristics, thereby allowing for multiple potential modeling approaches and structures. Various DCE-MRI modeling techniques are discussed in this article.

References

Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Dec 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K S St Lawrence, T Y Lee
Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·J L Evelhoch
May 30, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R E PortG Brix
Oct 13, 2001·Journal of Magnetic Resonance Imaging : JMRI·M RijpkemaA Heerschap
Dec 4, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thomas E YankeelovCharles S Springer
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cheng YangWalter M Stadler
May 5, 2005·British Journal of Cancer·M O LeachUNKNOWN Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee, Drug Development Office, Cancer Research UK
Jul 11, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nola Hylton
Oct 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Geoff J M ParkerGordon C Jayson
Jul 12, 2007·Journal of Magnetic Resonance Imaging : JMRI·Tristan BarrettPeter L Choyke
Apr 19, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Leanne R BerryRichard A D Carano
Sep 9, 2008·Journal of Magnetic Resonance Imaging : JMRI·Edward AshtonJeffrey Evelhoch
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wei HuangCharles S Springer
May 19, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaobing Fan, Gregory S Karczmar
May 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chris J RoseGeoffrey J M Parker
May 1, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gregory Z FerlRuediger E Port
Aug 18, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lucy E Kershaw, Hai-Ling Margaret Cheng
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 6, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T S KohZ Hou
Jul 26, 2011·Seminars in Nephrology·Richard N Hellman
Feb 15, 2012·Nature Reviews. Clinical Oncology·James P B O'ConnorGordon C Jayson

❮ Previous
Next ❯

Citations

Apr 23, 2014·Journal of Magnetic Resonance Imaging : JMRI·Gregory Z FerlRuediger E Port
Jan 19, 2016·Molecular Oncology·Elena Hernández-AgudoMiguel Quintela-Fandino
Aug 1, 2013·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Youngkyu SongJeong Kon Kim
Oct 29, 2015·Physics in Medicine and Biology·Maria A Schmidt, Geoffrey S Payne
Sep 13, 2016·Physics in Medicine and Biology·Manil D ChouhanStuart A Taylor
Sep 16, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Octavia BaneBachir Taouli
May 21, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanwei ChenGuanshu Liu
Jun 14, 2014·Journal of Magnetic Resonance Imaging : JMRI·Shimon AronhimeBachir Taouli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.