Quantification of aortic valvular regurgitation in dogs by nuclear imaging

Circulation
R H BaxterM L Weisfeldt

Abstract

Radionuclide gated cardiac blood pool (GBP) imaging was used to quantitatively assess the severity of acute aortic valvular regurgitation produced experimentally in 10 anesthetized dogs. Right ventricular (RV) and left ventricular (LV) stroke counts (end-diastolic minus end-systolic counts in RV and LV regions of interest) were used as indices of the stroke volumes of the two ventricles. Regurgitant fraction (RFGBP) was derived by assuming that an excess of LV stroke counts compared to RV stroke counts was due to regurgitant flow: RFGBP = LV stroke counts - RV stroke counts/LV stroke counts X 100. Regurgitant fraction (RFEMF) was also estimated directly from an electromagnetic flowmeter (EMF) on the ascending aorta. Mean RFEMF was 55.8 +/- 17.9% (+/-SD). Close agreement was found between regurgitant fractions measured by GBP and EMF (RFGBP = 1.09, RFEMF - 4.7%, r = 0.88, p less than 0.001, SEE = 9.98%). The severity of regurgitation from blood pool images also correlated closely with aortic pulse pressure (r = 0.89) and the length of the tear in the aortic valve (r = 0.84). These results suggest that blood pool imaging may be sueful for noninvasive quantification of regurgitant flow in patients with valvular insufficiency.

Citations

Jan 1, 1982·European Journal of Nuclear Medicine·M Chevigné, P Rigo
Jan 1, 1984·Journal of the American College of Cardiology·M C GersonR J Adolph
Oct 15, 1998·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·G B DanielD Schmidt
Dec 1, 1981·British Heart Journal·R ThompsonR Elmes
Jan 1, 1986·British Heart Journal·Y ZhangE Myhre
Feb 1, 1981·The American Journal of Cardiology·W LamK Rosen
Feb 1, 1983·The American Journal of Cardiology·R M SteingartJ Scheuer
Apr 1, 1982·American Heart Journal·H N Wagner
Dec 18, 1980·The American Journal of Cardiology·G P LeitlH N Wagner
Apr 3, 2019·Journal of Veterinary Internal Medicine·Julia BoegliKatharyn J Mitchell
Feb 1, 1981·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·W J HannanA L Muir
Sep 1, 1981·Postgraduate Medicine·J T WillersonR W Parkey

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