Quantification of arterial flow using digital subtraction angiography

Medical Physics
O BonnefousD Ruijters


In this paper, a method for the estimation of arterial hemodynamic flow from x-ray video densitometry data is proposed and validated using an in vitro setup. The method is based on the acquisition of three-dimensional rotational angiography and digital subtraction angiography sequences. A modest contrast injection rate (between 1 and 4 ml/s) leads to a contrast density that is modulated by the cardiac cycle, which can be measured in the x-ray signal. An optical flow based approach is used to estimate the blood flow velocities from the cyclic phases in the x-ray signal. The authors have validated this method in vitro, and present three clinical cases. The in vitro experiments compared the x-ray video densitometry results with the gold standard delivered by a flow meter. Linear correlation analysis and regression fitting showed that the ideal slope of 1 and intercept of 0 were contained within the 95 percentile confidence interval. The results show that a frame rate higher than 50 Hz allows measuring flows in the range of 2 ml/s to 6 ml/s within an accuracy of 5%. The in vitro and clinical results indicate that it is feasible to estimate blood flow in routine interventional procedures. The availability of an x-ray based method fo...Continue Reading


Jan 1, 1981·The Proceedings of the Nutrition Society·A J Webster
Jan 1, 1996·Ultrasound in Medicine & Biology·C K HollandT R McCauley
Jul 1, 1992·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P N Burns
Apr 13, 2005·IEEE Transactions on Medical Imaging·Kawal S RhodeAlexander M Seifalian
Aug 14, 2008·Medical Physics·Irina WaechterDavid J Hawkes
Jun 3, 2009·Journal of Neuroradiology. Journal De Neuroradiologie·L AugsburgerDaniel Rüfenacht
Sep 29, 2009·Annual Review of Fluid Mechanics·Daniel M SforzaJ R Cebral
Dec 10, 2009·Medical Physics·Baruch B LieberLiliana Cesar
Oct 29, 2010·Medical Engineering & Physics·G MulderF N van de Vosse
Nov 29, 2011·International Journal of Vascular Medicine·Xavier ArmoiryFrancis Turjman
May 1, 2012·Journal of Neurointerventional Surgery·Emanuela CrobedduH J Cloft


Mar 28, 2016·International Journal of Computer Assisted Radiology and Surgery·Marco BoegelMarkus Kowarschik
Jul 9, 2013·Computer Methods and Programs in Biomedicine·Tung-Hsin WuTzung-Chi Huang
Jan 26, 2013·European Journal of Radiology·Vitor M PereiraLovblad Karl-Olof
Feb 2, 2015·Journal of Biomechanics·H G Morales, O Bonnefous
Sep 17, 2016·AJNR. American Journal of Neuroradiology·H G MoralesI Larrabide
Apr 8, 2017·AJNR. American Journal of Neuroradiology·J R CebralD Ruijters
Jun 13, 2017·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Liang-Der Jou
Jan 18, 2014·Stroke; a Journal of Cerebral Circulation·Ajay K WakhlooL Pierot
Apr 19, 2017·Journal of Biomechanical Engineering·Zifeng YangBryan Ludwig
Dec 25, 2015·Journal of Neurointerventional Surgery·Marta Aguilar PérezV M Pereira
Nov 18, 2018·Journal of Magnetic Resonance Imaging : JMRI·Baohong WenBing Wu
May 3, 2019·Applied Optics·Zifeng Yang, Mark Johnson
Apr 23, 2020·Journal of Neurointerventional Surgery·Nicole Mariantonia CancelliereVitor M Pereira
Nov 26, 2020·Journal of Magnetic Resonance Imaging : JMRI·Sung Won Youn, Jongmin Lee
Apr 7, 2016·Topics in Magnetic Resonance Imaging : TMRI·V M PereiraMaria Isabel Vargas

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Carotid Arteries
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