Abstract
Conventional non-invasive imaging modalities of atherosclerosis such as coronary artery calcium (CAC) and carotid intimal medial thickness (C-IMT) provide information about the burden of disease. However, despite multiple validation studies of CAC, and C-IMT, these modalities do not accurately assess plaque characteristics, and the composition and inflammatory state of the plaque determine its stability and, therefore, the risk of clinical events. [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG) imaging using positron-emission tomography (PET)/computed tomography (CT) has been extensively studied in oncologic metabolism. Studies using animal models and immunohistochemistry in humans show that FDG-PET/CT is exquisitely sensitive for detecting macrophage activity, an important source of cellular inflammation in vessel walls. More recently, we and others have shown that FDG-PET/CT enables highly precise, novel measurements of inflammatory activity of activity of atherosclerotic plaques in large and medium-sized arteries. FDG-PET/CT studies have many advantages over other imaging modalities: 1) high contrast resolution; 2) quantification of plaque volume and metabolic activity allowing for multi-modal atherosclerotic plaque quantification;...Continue Reading
References
Jan 1, 1994·Circulation·A C van der WalP K Das
Jul 28, 1999·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·V M Gil
Dec 14, 1999·European Journal of Nuclear Medicine·R HustinxA Alavi
Sep 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Terence M DohertyTripathi B Rajavashisth
Apr 27, 2005·Hypertension·Paolo RaggiMatthew Budoff
Jul 5, 2005·Journal of the American College of Cardiology·Yadon AradAlan D Guerci
Mar 17, 2006·Atherosclerosis·Timothy S ChurchMilton Z Nichaman
Nov 7, 2006·Journal of the American College of Cardiology·Nobuhiro TaharaTsutomu Imaizumi
Nov 28, 2006·Nuclear Medicine and Biology·Gonca G BuralAbass Alavi
Jan 24, 2007·Circulation·Matthias W LorenzMatthias Sitzer
Jan 31, 2007·The American Journal of Cardiology·Sekar KathiresanChristopher J O'Donnell
Apr 10, 2007·Clinical Neurology and Neurosurgery·Antonio ArauzErik Alexanderson
Aug 28, 2007·Journal of the American College of Cardiology·James H F RuddZahi A Fayad
Oct 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Gonca G BuralAbass Alavi
Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Su Jin LeeKyung-Han Lee
Nov 5, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Wengen ChenAbass Alavi
May 9, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Johan A WasséliusHans Jacobsson
Sep 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Axel RomingerMarcus Hacker
Sep 29, 2009·The International Journal of Cardiovascular Imaging·John R DaviesElizabeth A Warburton
May 18, 2011·Archives of Dermatology·Nehal N MehtaJoel M Gelfand
Citations
Dec 25, 2012·Annals of Nuclear Medicine·Yoshiharu RyuHitoshi Shibuya
Nov 28, 2013·Inflammation·Mateja Kaja JezovnikPavel Poredos
Dec 4, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·André Luís Branco de BarrosAbass Alavi
Dec 3, 2014·PET Clinics·Sina HoushmandHabib Zaidi
Nov 3, 2012·Experimental Physiology·Adelaide GrecoAlberto Cuocolo
Jan 23, 2016·Radiology Research and Practice·Sunny GoelOn Chen
Feb 25, 2015·Academic Radiology·Emil M deGomaNehal N Mehta
Mar 27, 2015·The Journal of Dermatology·Sang Woong YounWon Woo Lee
Jun 21, 2016·PET Clinics·Søren HessSandip Basu
May 31, 2016·Journal of Atherosclerosis and Thrombosis·Pavel PoredosMateja Kaja Jezovnik
Jul 12, 2019·Nature Reviews. Rheumatology·Lyn D FergusonNaveed Sattar
Mar 5, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Charlotte L HarringtonNehal N Mehta
Dec 14, 2019·Current Rheumatology Reports·Harry ChoiNehal N Mehta
Oct 10, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Haley B NaikNehal N Mehta
Mar 16, 2017·Circulation. Cardiovascular Imaging·Alex T VeseyDavid E Newby
Jul 12, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Abass AlaviPoul Flemming Høilund-Carlsen
Apr 20, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Berit Dalsgaard NielsenEllen-Margrethe Hauge
Jan 9, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Abass AlaviAli Gholamrezanezhad
Apr 10, 2021·Nature Reviews. Rheumatology·Fabiola AtzeniZoltán Szekanecz
Apr 24, 2021·The Journal of Investigative Dermatology·Alvaro González-CanteroJoel M Gelfand
Jul 11, 2021·Scientific Reports·Elin GoodEbo de Muinck