PMID: 1212651Dec 1, 1975Paper

Quantification of carcinoembryonic antigen-like activities in normal, human gastrointestinal secretions

Cancer
V L GoS F Phillips

Abstract

The secretion of carcinoembryonic antigen-like (CEA-like) material into the gastrointestinal tract of 28 fasting normal men was quantified by using intestinal perfusion techniques. CEA-like material was recovered from all levels of the gastrointestinal tract. The highest secretory rate was in the colon (mean +/- SE, 2.41 +/- 2.0 mug/minute per colon), followed by pancreatobiliary secretion and pancreatic secretion. The secretory rate from the stomach, duodenum, jejunum, and ileum was less than 20 ng/minute. After perchloric acid extraction, the CEA-like material from the colon had the same chromatographic and radioimmunologic properties as [125I] CEA. These data suggest that the CEA-like material is normally secreted into the gastrointestinal tract and particularly into the colon.

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Citations

Jan 1, 1979·Acta neurochirurgica·E MiyakeF Ishigami
Jan 1, 1976·Journal of Surgical Oncology·M M Copeland
Jul 1, 1983·The Japanese Journal of Surgery·O KojimaY Fujita
Jan 1, 1980·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·J Lindgren
Nov 5, 1997·International Journal of Cancer. Journal International Du Cancer·F GuadagniJ Schlom
Feb 1, 1982·Current Problems in Surgery·H P EwingJ D Hardy

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