Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease

Circulation. Cardiovascular Imaging
Sang-Eun LeeHyuk-Jae Chang

Abstract

Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression. From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography >2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (△PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of △PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P<0.05). After risk adjustment, addition of baseline PB improved prediction of rapid progression to each angi...Continue Reading

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Citations

Jul 18, 2018·Circulation. Cardiovascular Imaging·Armin Arbab-Zadeh
Sep 21, 2019·Journal of the American College of Cardiology·Armin Arbab-Zadeh, Valentin Fuster
Jan 17, 2021·Journal of Cardiovascular Computed Tomography·Alexander R van RosendaelHyuk-Jae Chang
Aug 20, 2019·JACC. Cardiovascular Imaging·Armin Arbab-Zadeh
May 1, 2021·European Journal of Preventive Cardiology·Alexios S AntonopoulosDimitris Tousoulis
Aug 21, 2020·Journal of the American College of Cardiology·Erik B SchelbertChristopher A Miller
Jun 22, 2020·JACC. Cardiovascular Imaging·William S Weintraub, Armin Arbab-Zadeh
Sep 2, 2021·The American Journal of Cardiology·A Maxim BaxHyuk-Jae Chang
Aug 24, 2020·JACC. Cardiovascular Imaging·Sang-Eun LeeHyuk-Jae Chang

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