Quantification of diabetic macular ischemia using novel three-dimensional optical coherence tomography angiography metrics.

Journal of Biophotonics
Enrico BorrelliGiuseppe Querques

Abstract

We applied three-dimensional (3D) analysis to optical coherence tomography angiography (OCTA) to measure macular ischemia in eyes affected by non-proliferative diabetic retinopathy (DR). A previously validated algorithm was applied to OCTA data in order to obtain 3D visualization of the retinal vasculature. Successively, a global thresholding algorithm was applied and two novel quantitative metrics were introduced: 3D vascular volume and 3D perfusion density. Two-dimensional (2D) OCTA metrics were also obtained with different binarization thresholds for comparison. Of the 30 patients included, 15 were diagnosed with DR and 15 were controls. The 3D vascular volume and 3D perfusion density were reduced in DR eyes (P < .0001). The 2D variables also significantly differ between groups. The 3D perfusion density had the highest area under the receiver operating characteristic curve (0.964) among tested variables. Assessing quantitative perfusion using 3D analysis is reliable and promising, and with an elevated diagnostic efficacy in identifying DR eyes.

References

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Aug 4, 2018·Investigative Ophthalmology & Visual Science·Peter L Nesper, Amani A Fawzi
Mar 15, 2019·Ophthalmology and Therapy·Enrico BorrelliGiuseppe Querques
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Nov 16, 2019·Scientific Reports·Enrico BorrelliGiuseppe Querques
Jan 14, 2020·European Journal of Ophthalmology·Marco BattistaGiuseppe Querques

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Citations

Sep 6, 2020·Eye·Giuseppe QuerquesFrancesco Bandello
Jun 1, 2021·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Enrico BorrelliGiuseppe Querques
Jun 10, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Khalil Ghasemi FalavarjaniEsrafil Shad

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