Quantification of enhancement in contrast-enhanced spectral mammography using a custom-made quantifier tool (I-STRIP): A proof-of-concept study

European Journal of Radiology
M B I LobbesC R L P N Jeukens

Abstract

Contrast-enhanced spectral mammography (CESM) is diagnostically superior to full-field digital mammography. An important improvement for CESM would be the ability to quantify enhancement. In this proof-of-concept study we present a method for quantifying CESM enhancement. We developed a custom-made quantifier tool (I-STRIP) containing five chambers, each filled with a different iodine mass thickness (IMT). CESM grey values of the recombined image (CGV) in the I-STRIP were used to quantify breast IMT. We evaluated the I-STRIP's accuracy using a dedicated breast phantom containing chambers with known IMT's. Furthermore, we tested the effect of the I-STRIP on image quality and clinical use in five patients. Retrospectively, we studied whether current CESM protocols could distinguish between malignant and benign lesions in terms of CGV. Phantom experiments showed that quantification was independent of chamber height and size, phantom thickness and I-STRIP position for different IMT's (1.5, 3.0 and 7.5 mg l/cm2). Near the phantom's periphery accuracy was found to be lower due to the breast-within-breast artifact. In the clinical setting (n = 5), workflow and image quality were not influenced by the I-STRIP. The mean IMT of these inv...Continue Reading

Citations

Sep 8, 2021·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Anat Kornecki

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