PMID: 11322722Apr 27, 2001Paper

Quantification of fibre type regionalisation: an analysis of lower hindlimb muscles in the rat

Journal of Anatomy
L C Wang, D Kernell

Abstract

Newly developed concepts and methods for the quantification of fibre type regionalisation were used for comparison between all muscles traversing the ankle of the rat lower hindlimb (n = 12). For each muscle, cross-sections from the proximodistal midlevel were stained for myofibrillar ATPase and classified as type I ('slow') or II ('fast'). For the 11 'fast' muscles (i.e. all except soleus), the muscle outline and the position of each type I fibre were digitised for further computer processing. Two potentially independent aspects of type I fibre regionalisation were evaluated quantitatively: (1) the degree to which type I fibres were restricted to a limited portion of the total cross-sectional area ('area-regionalisation'): (2) the extent and direction of the difference (if any) between the centre of the muscle cross-section and the calculated centre for the type I fibre cluster ('vector regionalisation'). Statistical analysis showed that type I fibres were vector regionalised in practically all investigated muscles and area regionalised within most of them, the only consistent exceptions being peroneus brevis and peroneus digitorum 4, 5. In muscles with a high degree of area regionalisation the population of type I fibres also...Continue Reading

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Citations

Nov 26, 2015·Human Molecular Genetics·Peter I JoyceAbraham Acevedo-Arozena
Jul 27, 2011·Environmental Toxicology and Pharmacology·M Méndez-ArmentaC Rios
Jun 26, 2007·Toxicon : Official Journal of the International Society on Toxinology·Carina T RizziLanfranco R P Troncone
Jun 10, 2009·Journal of Cellular Biochemistry·Peter SogaardAlexander V Chibalin
Jan 14, 2010·Journal of Cellular Biochemistry·Peter SogaardJuleen R Zierath
Sep 7, 2016·Experimental Neurology·Tessa Gordon, Joanne E Totosy de Zepetnek
Feb 20, 2018·The Journal of Physiology·Andreas BossArend Heerschap
Oct 17, 2017·Toxicologic Pathology·Kathryn E Gropp
Mar 21, 2013·Muscle & Nerve·Ioannis P KalpidisMaria Albani
Dec 18, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Fabian NiessMartin Meyerspeer
Jul 30, 2017·Calcified Tissue International·A López-HerradónA Ortega-de Mues
Jul 1, 2008·The Journal of Experimental Biology·Timothy E Higham, Andrew A Biewener
Jun 10, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Celine BaligandHermien E Kan

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