Quantification of Geographic Atrophy Using Spectral Domain OCT in Age-Related Macular Degeneration.

Ophthalmology Retina
Spencer C ClelandAmitha Domalpally

Abstract

To compare geographic atrophy (GA) area and enlargement rate measured with spectral domain OCT (SD-OCT) with fundus autofluorescence (FAF), color fundus photography (CFP), and infrared reflectance (IR) imaging. Retrospective, multicenter, natural history case series. A total of 70 eyes with GA from 48 participants were included. Participants underwent SD-OCT, FAF, CFP, and IR imaging at baseline and 12 months in the study eye. Spectral domain OCT images were graded for GA area using 2 distinct criteria: (1) complete retinal pigment epithelium and outer retinal atrophy (cRORA) and (2) hypertransmission through Bruch's membrane. Areas were measured with SD-OCT using a custom-developed tool that allows for mapping areas of retinal layer loss on SD-OCT cross-sectional scans with co-registered IR images. Circularity index was calculated from area and perimeter. Spectral domain OCT images were also assessed for presence of reticular pseudodrusen, outer-retinal tubules, and hyporeflective wedge-shaped bands. Area of GA was measured in millimeters squared from FAF, CFP, and IR images. Geographic atrophy mean baseline area and enlargement rate measured with 2 SD-OCT criteria, FAF, CFP, and IR. At baseline, the mean GA area was 6.9 (stan...Continue Reading

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Citations

Feb 5, 2021·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Giulia CorradettiDavid Sarraf
Mar 21, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Aneesha AhluwaliaLucian V Del Priore

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