Quantification of hydrogen cyanide in humid air by selected ion flow tube mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
P SpanelD Smith

Abstract

Following our recent observation that Pseudomonas bacteria in vitro emit hydrogen cyanide, we have found it necessary to investigate the ion chemistry of this compound and to extend the kinetics database for selected ion flow tube mass spectrometry (SIFT-MS) to allow the accurate quantification of HCN in moist air samples, including exhaled breath. Because of the proximity of the proton affinities of HCN and H2O molecules, the presence of water vapour can significantly distort HCN analysis in the presence of water vapour and a more sophisticated analytical procedure has to be developed. Thus, the reactions of H3O+(H2O)0,1,2,3 ions with HCN molecules have been studied in the presence of varying concentrations of water vapour, reactions on which SIFT-MS analysis of HCN relies. The results of these experiments have allowed an analytical procedure to be developed which has extended the kinetics database of SIFT-MS, such that HCN can now be quantified in humid air and in exhaled breath.

Citations

Oct 21, 2004·Mass Spectrometry Reviews·David Smith, Patrik Spanel
Nov 9, 2004·Journal of Mass Spectrometry : JMS
Jul 22, 2010·Mass Spectrometry Reviews·Patrik Spaněl, David Smith
Aug 14, 2013·Rapid Communications in Mass Spectrometry : RCM·Kseniya DryahinaDavid Smith
Dec 7, 2005·Rapid Communications in Mass Spectrometry : RCM·Tianshu WangDavid Smith
Feb 17, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·R D AndersonD W Reid
Dec 1, 2007·Journal of Breath Research·Patrik SpanelDavid Smith
Apr 7, 2009·Rapid Communications in Mass Spectrometry : RCM·David SmithPatrik Spanel
Apr 15, 2010·Rapid Communications in Mass Spectrometry : RCM·Kseniya DryahinaP Spanel
Apr 1, 2014·Journal of Breath Research·David SmithJonathan Beauchamp
Nov 30, 2013·Journal of Breath Research·David SmithWarren Lenney
Mar 25, 2011·The Analyst·David Smith, Patrik Spaněl
Mar 1, 2014·European Journal of Mass Spectrometry·Patrik Spanel, David Smith
Dec 5, 2009·The Journal of Physical Chemistry. a·Alina Silvia ChiperChristian Postel

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