Quantification of Incensole in Three Boswellia Species by NIR Spectroscopy Coupled with PLSR and Cross-Validation by HPLC

Phytochemical Analysis : PCA
Sulaiman Al-ShidhaniAhmed Al-Harrasi

Abstract

Incensole can be considered as a biomarker for Boswellia species which is a diterpene that has received remarkable pharmacological interest recently due to its potent anti-inflammatory and anti-depressant activity. Near-infrared (NIR) spectroscopy coupled with PLSR (partial least squares regression) as a robust, rapid and alternative method was used to quantify the content of incensole in three species namely B. papyrifera, B. sacra and B. serrata and cross-validated by high-performance liquid chromatography (HPLC). NIR spectrophotometer was used for the quantification of incensole standards and Boswellia species in absorption mode in the wavelength range between 700 and 2500 nm. A PLSR model was built from the obtained spectral data using 70% of the incensole working standard solutions (training set), ranging from 0.5 to 100 ppm. The PLSR model obtained has a R2 value of 98% with a correlationship of 0.99 and a good prediction with root mean square error for prediction (RMSEP) value of 3.2%. The results indicated that the methanol (MeOH) extract of B. papyrifera resin has the highest concentration of incensole (18.4%) followed by n-hexane (13.5%) and ethyl acetate (3.6%) while trace amounts was detected in the fractions of B. ...Continue Reading

References

Aug 27, 2003·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Farid A BadriaMohamed M A Amer
Feb 26, 2005·Journal of Natural Products· Atta-ur-RahmanM Iqbal Choudhary
Aug 1, 1987·Planta medica·S M WahabB El-Fallaha
May 20, 2017·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ahmed Al-HarrasiSaif Alameri

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Citations

Nov 4, 2020·Journal of Pharmaceutical and Biomedical Analysis·Krzysztof B BećChristian W Huck
Aug 20, 2021·Phytochemistry·Ahmed Al-HarrasiBiswanath Das

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