Quantification of infarct size and myocardium at risk: evaluation of different techniques and its implications

European Heart Journal Cardiovascular Imaging
Elisa McAlindonChiara Bucciarelli-Ducci

Abstract

The aim of this study was to evaluate seven methods for quantifying myocardial oedema [2 standard deviation (SD), 3 SD, 5 SD, full width at half maximum (FWHM), Otsu method, manual thresholding, and manual contouring] from T2-weighted short tau inversion recovery (T2w STIR) and also to reassess these same seven methods for quantifying acute infarct size following ST-segment myocardial infarction (STEMI). This study focuses on test-retest repeatability while assessing inter- and intraobserver variability. T2w STIR and late gadolinium enhancement (LGE) are the most widely used cardiovascular magnetic resonance (CMR) techniques to image oedema and infarction, respectively. However, no consensus exists on the best quantification method to be used to analyse these images. This has potential important implications in the research setting where both myocardial oedema and infarct size are increasingly used and measured as surrogate endpoints in clinical trials. Forty patients day 2 following acute reperfused STEMI were scanned for myocardial oedema and infarction (LGE). All patients had a second CMR scan on the same day >6 h apart from the first one. Images were analysed offline by two independent observers using the semi-automated sof...Continue Reading

References

Apr 1, 1996·Radiology·O P SimonettiD A Henry
Dec 21, 2004·Journal of the American College of Cardiology·Luciano C AmadoJoão A C Lima
May 11, 2005·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Olga BondarenkoAlbert C van Rossum
Apr 19, 2008·Journal of the American College of Cardiology·Matthias G FriedrichRainer Dietz
Mar 11, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Aernout M BeekAlbert C van Rossum
Sep 17, 2009·The International Journal of Cardiovascular Imaging·A M BeekA C van Rossum
May 4, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Peder SörenssonHåkan Arheden
Feb 22, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Ingo Eitel, Matthias G Friedrich
Mar 19, 2011·JACC. Cardiovascular Imaging·David VerhaertSubha V Raman
Aug 9, 2011·Journal of Cardiovascular Pharmacology and Therapeutics·Andrew E Arai
Sep 17, 2011·JACC. Cardiovascular Imaging·Matthias G FriedrichRaymond J Kim
Feb 2, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Jane SjögrenEinar Heiberg
Aug 28, 2012·European Heart Journal·Kristian ThygesenUNKNOWN ESC Committee for Practice Guidelines (CPG)
May 3, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Jeanette Schulz-MengerEike Nagel
Dec 1, 2012·Global Heart·Kristian ThygesenHarvey D White

❮ Previous
Next ❯

Citations

Jan 25, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Stephen HamshereAnthony Mathur
Jun 5, 2015·International Journal of Cardiology·Kirian van der WegMitchell W Krucoff
Jan 1, 2016·Heart·Amardeep Ghosh DastidarChiara Bucciarelli-Ducci
Dec 25, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Chiara Bucciarelli-DucciAngelo Auricchio
Mar 28, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Xiao-Ming GaoXiao-Jun Du
Feb 2, 2017·World Journal of Radiology·Carlo N De CeccoU Joseph Schoepf
Feb 9, 2018·Journal of the American Heart Association·Choukri MekkaouiDavid E Sosnovik
Nov 24, 2018·Korean Circulation Journal·Sang Eun LeeHyuk Jae Chang
Oct 26, 2018·The International Journal of Cardiovascular Imaging·Amardeep Ghosh DastidarChiara Bucciarelli-Ducci
Oct 7, 2017·European Heart Journal Cardiovascular Imaging·Thor EdvardsenBogdan A Popescu
Aug 3, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Heerajnarain BulluckDerek J Hausenloy
Mar 1, 2019·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christoph GräniRaymond Y Kwong
Sep 21, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Valentina O PuntmannUNKNOWN SCMR Clinical Trial Writing Group
Nov 6, 2020·Der Radiologe·A MayrD Beitzke
Oct 27, 2020·The International Journal of Cardiovascular Imaging·D BeitzkeC Loewe
Jun 8, 2021·European Heart Journal Cardiovascular Imaging·Ana G AlmeidaUNKNOWN 2018–2020 EACVI President:

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01468662

Software Mentioned

Otsu
APPROACH
CMR42 Circle

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.