Quantification of inhaled aerosol particles composed of toxic household disinfectant using radioanalytical method

Chemosphere
Ha Eun ShimJongho Jeon

Abstract

To assess the risk posed by a toxic chemical to human health, it is essential to quantify its uptake in a living subject. This study aims to investigate the biological distribution of inhaled polyhexamethylene guanidine (PHMG) aerosol particle, which is known to cause severe pulmonary damage. By labeling with indium-111 (111In), we quantified the uptake of PHMG for up to 7 days after inhalation exposure in rats. The data demonstrate that PHMG is only slowly cleared, with approximately 74% of inhaled particles persisting in the lungs after 168 h. Approximately 5.3% of inhaled particles were also translocated to the liver after 168 h, although the level of redistribution to other tissues, including the kidneys and spleen, was minimal. These observations suggest that large uptake and slow clearance may underlie the fatal inhalation toxicity of PHMG in humans.

Citations

Mar 21, 2020·Advanced Healthcare Materials·Ali FarzinAli Tamayol
Feb 7, 2020·Clinical and Experimental Pediatrics·Eun LeeSoo-Jong Hong
Jul 23, 2020·Environmental Analysis, Health and Toxicology·Jong Han Leem, Hwan-Cheol Kim
May 15, 2019·International Journal of Molecular Sciences·Jongho Jeon
Sep 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae Young LeeJongho Jeon

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