Quantification of insulin release from implantable polymer-based delivery systems and augmentation of therapeutic effect with simultaneous release of somatostatin

Journal of Pharmaceutical Sciences
E R EdelmanR Langer

Abstract

Insulin injections control diabetes mellitus but do not reproduce physiologic regulation. Polymer-based controlled-release technology has enabled us to demonstrate: that the controlled release of insulin from polymer matrices can indeed be used to control diabetes mellitus but does so at the expense of hyperinsulinemia and hypoglycemia; and that somatostatin can be delivered in similar fashion, so as to provide glucose homeostasis in a more physiologic range, at lower insulin levels and at somatostatin doses below those used in intermittent infusion studies; and, that microgram quantities of a drug can be delivered successfully in vivo with intact biological function and in a manner that can be monitored continuously. In the present study the simultaneous polymer-matrix-controlled release of insulin with somatostatin extended glycemic control in diabetic rats. Eleven rats received subcutaneous polymer matrix implants containing insulin alone and 11 rats received implants containing insulin and somatostatin. Plasma and urinary glucose control were improved in both groups. Glucose concentrations in the insulin alone group remained depressed for 5 days until insulin release from the matrices declined below 11.6 units/kg/day. When ...Continue Reading

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Citations

Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H ReithmeierA Göpferich
May 5, 2001·International Journal of Pharmaceutics·H ReithmeierA Göpferich
Apr 16, 2010·Science Translational Medicine·Larry Brown, Elazer R Edelman
Jan 15, 2008·Urologic Oncology·Frank AlexisOmid C Farokhzad
Sep 8, 2010·Advanced Materials·Brian P TimkoDaniel S Kohane
Nov 28, 2012·Advanced Healthcare Materials·Kaitlin M BratlieDaniel G Anderson

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