Quantification of interplay and gradient effects for lung stereotactic ablative radiotherapy (SABR) treatments

Journal of Applied Clinical Medical Physics
Madelaine K Tyler

Abstract

This study quantified the interplay and gradient effects on GTV dose coverage for 3D CRT, dMLC IMRT, and VMAT SABR treatments for target amplitudes of 5-30 mm using 3DVH v3.1 software incorporating 4D Respiratory MotionSim (4D RMS) module. For clinically relevant motion periods (5 s), the interplay effect was small, with deviations in the minimum dose covering the target volume (D99%) of less than ± 2.5% for target amplitudes up to 30 mm. Increasing the period to 60 s resulted in interplay effects of up to ± 15.0% on target D99% dose coverage. The gradient effect introduced by target motion resulted in deviations of up to ± 3.5% in D99% target dose coverage. VMAT treatments showed the largest deviation in dose metrics, which was attributed to the long delivery times in comparison to dMLC IMRT. Retrospective patient analysis indicated minimal interplay and gradient effects for patients treated with dMLC IMRT at the NCCI.

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Citations

Jul 1, 2018·Journal of Applied Clinical Medical Physics·Marguerite TyranHugues Mailleux
Sep 21, 2019·Journal of Applied Clinical Medical Physics·Makoto SasakiTakashi Mizowaki
Apr 3, 2019·International Journal of Clinical Oncology·Hiroshi DoiYasumasa Nishimura
Feb 6, 2021·Physical and Engineering Sciences in Medicine·Deepak ThaperHanuman P Yadav

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Software Mentioned

Monaco
Focal 4D
ArcCHECK
Respiratory 4D MotionSim
4D
RMS
3DVH
VMAT

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