Quantification of intra-fraction motion in breast radiotherapy using supine magnetic resonance imaging

Physics in Medicine and Biology
Tristan C F van HeijstBram van Asselen

Abstract

In early-stage breast-cancer patients, accelerated partial-breast irradiation techniques (APBI) and hypofractionation are increasingly implemented after breast-conserving surgery (BCS). For a safe and effective radiation therapy (RT), the influence of intra-fraction motion during dose delivery becomes more important as associated fraction durations increase and targets become smaller. Current image-guidance techniques are insufficient to characterize local target movement in high temporal and spatial resolution for extended durations. Magnetic resonance imaging (MRI) can provide high soft-tissue contrast, allow fast imaging, and acquire images during longer periods. The goal of this study was to quantify intra-fraction motion using MRI scans from 21 breast-cancer patients, before and after BCS, in supine RT position, on two time scales. High-temporal 2-dimensional (2D) MRI scans (cine-MRI), acquired every 0.3 s during 2 min, and three 3D MRI scans, acquired over 20 min, were performed. The tumor (bed) and whole breast were delineated on 3D scans and delineations were transferred to the cine-MRI series. Consecutive scans were rigidly registered and delineations were transformed accordingly. Motion in sub-second time-scale (deriv...Continue Reading

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Citations

Aug 21, 2016·The Breast : Official Journal of the European Society of Mastology·Maria Cristina LeonardiBarbara Alicja Jereczek-Fossa
Sep 7, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rosalinda RicottiBarbara Alicja Jereczek-Fossa
May 4, 2017·Acta Oncologica·Christer Andre JensenJomar Frengen
Aug 28, 2020·Frontiers in Oncology·Maureen L Groot KoerkampAnna M Kirby
Apr 3, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nienke HoekstraJean-Philippe Pignol

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