PMID: 9163579Mar 12, 1997Paper

Quantification of Locusta diuretic hormone in the central nervous system and corpora cardiaca: influence of age and feeding status, and mechanism of release

Regulatory Peptides
N AudsleyG M Coast

Abstract

Locusta-DH is known to have a hormonal function in the control of post-feeding diuresis in the migratory locust. This study has quantified Locusta-DH in tissues from V(th) instar nymphs and adults, and investigated the K+-induced release of the peptide from corpora cardiaca. Locusta-DH is present in thoracic and abdominal ganglia, but the amounts are small (25-200 fmol) compared with brain (approximately 1 pmol) and corpora cardiaca ( > 5 pmol) from 14-day old locusts. About 50% of the immunoreactive material in corpora cardiaca coelutes with Locusta-DH on reversed-phase HPLC. An earlier eluting fraction is also biologically active, suggesting locusts have a second, previously undetected, CRF-related peptide. The amount of peptide stored in corpora cardiaca varies with age and physiological status. Reductions on day 1 of the adult instar and immediately after feeding suggest Locusta-DH controls post-eclosion as well as post-feeding diureses. Locusta-DH is released by a Ca2+-dependent mechanism from corpora cardiaca held in salines containing > or =40 mM K+. This is blocked by verapamil, implicating L-type Ca2+ channels. Release is most rapid shortly after transfer to a high K+ saline, and more peptide is released from glands al...Continue Reading

References

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Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H KataokaD A Schooley

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Citations

Feb 11, 2003·Peptides·Richard A EigenheerDavid A Schooley
Dec 8, 2009·Annual Review of Entomology·Klaus W BeyenbachJulian A T Dow
Sep 9, 2008·General and Comparative Endocrinology·N Audsley, R J Weaver
Aug 1, 2015·Insect Biochemistry and Molecular Biology·Neil Audsley, Rachel E Down
Mar 19, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Atish RayShelley Bhattacharya

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