PMID: 9186535Apr 1, 1997Paper

Quantification of loss of haemoglobin components from the circulating red blood cell in vivo

European Journal of Haematology
F L WillekensJ M Werre

Abstract

Previous studies have shown that a considerable amount of haemoglobin is lost from the intact red cell during its lifespan. The aim of this study was to determine the relative contribution of all the haemoglobin components to this process. Therefore, the relative amount of haemoglobins A0, A2, F and the glycated haemoglobins were determined in 24 fractions of different cell age. These fractions were obtained by the combination of counterflow and density centrifugation. When the absolute amount of all haemoglobin components were calculated using the MCH-values of each fraction, it appeared that the mean red cell loss of haemoglobins A0, A2, F, an unknown X and "rest" comprised, respectively, 440, 23, 1, 4 and 1 amol per cell, while the mean gain of the glycated haemoglobins was 84 amol per cell. This resulted in a net loss of 385 amol of haemoglobin per cell. One of the glycated haemoglobins (HbA1e2) turned out to be the product of further carbamylation. It was concluded that in the first half of the red cell lifespan HbA0 and HbA2 decreased by glycation and carbamylation and that in the second half some of the HbA0 and HbA2 but also some of the glycated and carbamylated haemoglobin components leave the red cell. The total loss ...Continue Reading

References

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Citations

May 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Michael R CondonZoltán Spolarics
Aug 27, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Giel J C G M BosmanJan M Werre
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Aug 22, 2013·Microscopy Research and Technique·Timothy MooreVitaly Vodyanoy
Feb 6, 2013·Nutrition & Diabetes·M J AlkhatatbehL F Lincz
Jun 26, 2018·Frontiers in Physiology·Joames K F LealGiel J C G M Bosman
Dec 31, 2020·International Journal of Molecular Sciences·Kiruphagaran ThangarajuPaul W Buehler
Feb 20, 2020·Peptides·Fengmei WeiYuhong Jing
Jul 1, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Frederiek E VosRobert J Walker
Sep 29, 2011·Journal of Theoretical Biology·Julia KorellStephen B Duffull

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