Quantification of Mouse Renal Perfusion Using Arterial Spin Labeled MRI at 1 T

Academic Radiology
Quyen N DoRobert E Lenkinski

Abstract

Quantitative measurement of renal perfusion in murine models provides important information on the organ physiology and disease states. The 1-T desktop magnetic resonance imaging has a small footprint and a self-contained fringe field. This resultant flexibility in siting makes the system ideal for preclinical imaging research. Our objective was to evaluate the capability of the 1-T desktop magnetic resonance imaging to measure mouse renal perfusion without the administration of exogenous contrast agents. We implemented a flow-sensitive alternating inversion recovery (FAIR)-based arterial spin labeling sequence with a mouse volume coil on a 1-T desktop magnetic resonance scanner. The validity of the implementation was tested by comparing obtained renal perfusion results with literature values for normal mice and challenging the technique with mice treated with furosemide, a blood vessel vasoconstrictor drug. The measured cortical and medullary perfusions were quantified to be 402 ± 95 and 184 ± 52 mL/100 g/min, respectively, in agreement with literature values. The ratio of cortical to medullary renal blood flow was between 2 and 3 and was independent of the mouse weight. As expected, upon furosemide injection, a decrease (~50%...Continue Reading

References

Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D C Alsop, J A Detre
Nov 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Weiying DaiDavid C Alsop
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·A Dean SherryRobert E Lenkinski
Aug 7, 2012·European Radiology·Henrik S ThomsenUNKNOWN ESUR Contrast Medium Safety Committee
Sep 11, 2012·Academic Radiology·Jing WangXuexiang Jiang
Nov 23, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X ZhangM J P van Osch
Apr 10, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Guillaume DuhamelPatrick J Cozzone
Apr 18, 2013·NMR in Biomedicine·Reshmi RajendranKai-Hsiang Chuang
Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel
Feb 9, 2016·Cell·Christopher T HensleyRalph J DeBerardinis

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Citations

Aug 28, 2019·Journal of Magnetic Resonance Imaging : JMRI·Jeff L Zhang, Vivian S Lee

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