Quantification of Mycobacterium bovis transmission in a badger vaccine field trial

Preventive Veterinary Medicine
Inma AznarM C de Jong

Abstract

In the UK and Ireland, Bacille Calmette-Guérin (BCG) vaccination of badgers has been suggested as one of a number of strategies to control or even eradicate Mycobacterium bovis infection in badgers. In this manuscript, we present the results of a badger field trial conducted in Ireland and discuss how the novel trial design and analytical methods allowed the effects of vaccination on protection against infection and, more importantly, on transmission to be estimated. The trial area was divided into three zones North to South (A, B and C) where vaccination coverages of 0, 50 and 100%, respectively, were applied. Badgers were trapped over a 4year period. Badgers were assigned to either placebo or vaccine treatment, with treatment allocation occurring randomly in zone B. Blood samples were collected at each capture, and serology was performed in these samples using a chemiluminescent multiplex ELISA system (Enfer test). The analysis aimed to compare new infections occurring in non-infected non-vaccinated badgers to those in non-infected vaccinated ones, while accounting for the zone in which the badger was trapped and the infection pressure to which this individual badger was exposed. In total, 440 records on subsequent trappings ...Continue Reading

Citations

Jan 19, 2019·Veterinary Medicine and Science·Jose A Infantes-LorenzoFrancisco J Salguero
Jun 19, 2020·Pathogens·Ana BalseiroMaría A Risalde
Nov 22, 2018·Frontiers in Veterinary Science·Graham C Smith, Richard J Delahay
Nov 13, 2018·Frontiers in Veterinary Science·Bryce M BuddleLin-Mari de Klerk-Lorist
Dec 4, 2019·Frontiers in Veterinary Science·Simon J More
Sep 11, 2020·Preventive Veterinary Medicine·Freya SmithRichard J Delahay
Jul 28, 2021·Animal : an International Journal of Animal Bioscience·A Doeschl-WilsonS J More

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