Quantification of myocardial iron overload by cardiovascular magnetic resonance imaging T2* and review of the literature.

Clinical Cardiology
Ashok K KondurLuis Afonso

Abstract

Heart failure due to myocardial iron overload remains the leading cause of death in patients with transfusion-dependent anemias. Iron overload-induced cardiomyopathy is reversible if intensive chelation therapy is instituted on time. Thus, early detection of myocardial iron deposition is imperative to prevent overt heart failure. Conventional cardiac monitoring, including physical examination, electrocardiography, echocardiography or serum ferritin levels fail to predict manifest or subclinical myocardial involvement resulting from iron overload. Cardiovascular magnetic resonance imaging T2* (cMRI-T2*, pronounced T2 star) times correlate well with myocardial iron levels. This timely review focuses on the utility of cMRI-T2*, for the preclinical detection of myocardial iron overload and monitoring of myocardial iron content during chelation therapy.

References

Aug 1, 1971·The American Journal of Medicine·L M Buja, W C Roberts
Jan 1, 1980·Annals of the New York Academy of Sciences·A W NienhuisW F Anderson
Oct 28, 2003·Journal of Magnetic Resonance Imaging : JMRI·Mark A WestwoodDudley J Pennell
Dec 21, 2004·British Journal of Haematology·M A WestwoodD J Pennell
Dec 6, 2005·Journal of Magnetic Resonance Imaging : JMRI·Nilesh R GhugreJohn C Wood
Aug 5, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nilesh R GhugreJohn C Wood
Jan 20, 2007·The International Journal of Cardiovascular Imaging·Sophie MavrogeniDennis V Cokkinos

❮ Previous
Next ❯

Citations

Feb 26, 2013·AJR. American Journal of Roentgenology·Kirk J GiesbrandtPatricia J Mergo
May 1, 2012·Archives of Pathology & Laboratory Medicine·Sharif AliNalini Janakiraman
Jun 8, 2013·The International Journal of Cardiovascular Imaging·Mohamed AissiouDaniel Curnier
Oct 7, 2011·Clinical Radiology·A GuptaS Sharma
Mar 22, 2014·American Journal of Hematology·Diana X Nichols-VinuezaEllis J Neufeld
Sep 8, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sebastian WeingärtnerMehmet Akçakaya
Dec 17, 2017·Medicine·Sigitas ChmieliauskasSonata Jarmalaite
Apr 20, 2019·Postgraduate Medicine·Amal PaulSunil K Nadar
Jul 3, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Antonella MeloniThoralf Niendorf
Apr 19, 2020·European Radiology Experimental·E E NazarovaG A Novichkova
Nov 7, 2019·International Journal of Molecular Sciences·Joseph FranklOrhan K Öz
Oct 23, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Erin S GrantDavid A Simpson
Oct 9, 2021·The International Journal of Cardiovascular Imaging·Fadime Ersoy DursunOnur İncealtın

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.