Quantification of particle residence time in abdominal aortic aneurysms using magnetic resonance imaging and computational fluid dynamics

Annals of Biomedical Engineering
Ga-Young SuhCharles A Taylor


Hemodynamic conditions are hypothesized to affect the initiation, growth, and rupture of abdominal aortic aneurysms (AAAs), a vascular disease characterized by progressive wall degradation and enlargement of the abdominal aorta. This study aims to use magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) to quantify flow stagnation and recirculation in eight AAAs by computing particle residence time (PRT). Specifically, we used gadolinium-enhanced MR angiography to obtain images of the vessel lumens, which were used to generate subject-specific models. We also used phase-contrast MRI to measure blood flow at supraceliac and infrarenal locations to prescribe physiologic boundary conditions. CFD was used to simulate pulsatile flow, and PRT, particle residence index, and particle half-life of PRT in the aneurysms were computed. We observed significant regional differences of PRT in the aneurysms with localized patterns that differed depending on aneurysm geometry and infrarenal flow. A bulbous aneurysm with the lowest mean infrarenal flow demonstrated the slowest particle clearance. In addition, improvements in particle clearance were observed with increase of mean infrarenal flow. We postulate that augmentation ...Continue Reading


May 1, 1979·Microvascular Research·T Karino, H L Goldsmith
May 1, 1979·Microvascular Research·T Karino, H L Goldsmith
Oct 7, 1989·Lancet·J F VollmarA Friesch
Jan 1, 1987·Journal of Biomechanics·K Perktold
Jan 1, 1974·Journal of Biomechanics·J K RainesA H Shapiro
Nov 1, 1995·Journal of Clinical Epidemiology·R F Gillum
Aug 1, 1994·Journal of Biomechanical Engineering·J E Moore, D N Ku
Mar 1, 1994·Canadian Journal of Physiology and Pharmacology·A R Gear
Apr 1, 1996·Journal of Vascular Surgery·J SattaT Juvonen
May 1, 1996·Journal of Biomechanical Engineering·M J KunovC R Ethier
Aug 1, 1996·Journal of Biomechanical Engineering·Danny BluesteinM K Dewanjee
Mar 1, 1997·Annals of Biomedical Engineering·Danny BluesteinM K Dewanjee
Jun 9, 1999·Journal of Vascular Surgery·Charles A TaylorChristopher K Zarins
Nov 24, 1999·Journal of Biomechanics·C J EgelhoffK H Johansen
Mar 27, 2001·Computer Methods in Biomechanics and Biomedical Engineering·A Leuprecht, K Perktold
Nov 5, 2002·The American Journal of Pathology·Vincent FontaineJean-Baptiste Michel
Apr 11, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Beverly T TangCharles A Taylor
Dec 6, 2006·Journal of Vascular Surgery·Janice J YeungRonald L Dalman
Dec 22, 2006·Annals of the New York Academy of Sciences·Ronald L DalmanCharles A Taylor
May 29, 2007·Thrombosis Research·Anna M FallonAjit P Yoganathan
Dec 3, 2008·Circulation·Jonathan GolledgePaul E Norman
Feb 9, 2010·Computer Methods in Biomechanics and Biomedical Engineering·I E Vignon-ClementelCharles A Taylor
Mar 31, 2010·Annals of Biomedical Engineering·Ryan L Spilker, Charles A Taylor


Sep 21, 2013·Physics of Fluids·Mahdi Esmaily-MoghadamAlison L Marsden
Sep 7, 2012·Physics of Fluids·Amirhossein Arzani, Shawn C Shadden
Apr 6, 2013·International Journal for Numerical Methods in Biomedical Engineering·Vincent DuvernoisShawn C Shadden
Dec 12, 2012·International Journal for Numerical Methods in Biomedical Engineering·David HardmanPeter R Hoskins
Nov 30, 2012·Computational and Mathematical Methods in Medicine·Jürgen EndresArnd Dörfler
Jul 26, 2014·Annals of Biomedical Engineering·Shawn C Shadden, Amirhossein Arzani
Jun 2, 2016·Computational and Mathematical Methods in Medicine·Siang Lin Yeow, Hwa Liang Leo
Aug 20, 2016·Biomechanics and Modeling in Mechanobiology·Bruno GuerciottiRoberto Scrofani
Aug 30, 2016·International Journal for Numerical Methods in Biomedical Engineering·P Di AchilleJ D Humphrey
Feb 16, 2018·Computer Methods in Biomechanics and Biomedical Engineering·Mohammadali SharzeheeHai-Chao Han
Sep 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·D Julian A ScottRobert A S Ariëns
Sep 29, 2011·Korean Circulation Journal·Byoung-Kwon Lee
Dec 23, 2014·Journal of Biomechanical Engineering·Mahdi Esmaily-MoghadamAlison L Marsden
Oct 19, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Amirhossein ArzaniShawn C Shadden
Dec 10, 2016·Annals of Biomedical Engineering·Adam UpdegroveShawn C Shadden
Aug 24, 2012·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Malachy J O'RourkeSinead Kelly
May 9, 2014·The International Journal of Artificial Organs·Mona AlimohammadiVanessa Díaz-Zuccarini
Oct 19, 2019·Computer Methods and Programs in Biomedicine·Mehul VarshneyAbdullah Y Usmani
Apr 28, 2020·Computer Methods in Applied Mechanics and Engineering·Casey M FleeterAlison L Marsden
Apr 8, 2019·Journal of Biomechanics·Mirza Md Symon Reza, Amirhossein Arzani

Related Concepts

Blood Flow Velocity
In Silico
Particle Size
Aortic Aneurysm, Abdominal
Perfusion Magnetic Resonance Imaging
Gastritis, Hypertrophic
Magnetic Resonance Imaging
Vascular Diseases

Related Feeds


Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.