Quantification of serial changes in cerebral blood volume and metabolism in patients with recurrent glioblastoma undergoing antiangiogenic therapy

European Journal of Radiology
Andreas StadlbauerGertraud Heinz

Abstract

To evaluate the usefulness of quantitative advanced magnetic resonance imaging (MRI) methods for assessment of antiangiogenic therapy (AAT) response in recurrent glioblastoma multiforme (GBM). Eighteen patients with recurrent GBM received bevacizumab and 18 patients served as control group. Baseline MRI and two follow-up examinations were acquired every 3-5 months using dynamic susceptibility-weighted contrast (DSC) perfusion MRI and (1)H-MR spectroscopic imaging ((1)H-MRSI). Maps of absolute cerebral blood volume (aCBV) were coregistered with choline (Cho) and N-acetyl-aspartate (NAA) concentrations and compared to usually used relative parameters as well as controls. Perfusion significantly decreased in responding and pseudoresponding GBMs but also in normal appearing brain after AAT onset. Cho and NAA concentrations were superior to Cr-ratios in lesion differentiation and showed a clear gap between responding and pseudoresponding lesions. Responders to AAT exceptionally frequently (6 out of 8 patients) showed remote GBM progression. Quantification of CBV reveals changes in normal brain perfusion due to AAT, which were not described so far. DSC perfusion MRI seems not to be suitable for differentiation between response and ps...Continue Reading

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Citations

Sep 12, 2015·Future Oncology·Enrico FranceschiAlba A Brandes
Jul 5, 2016·Journal of Magnetic Resonance Imaging : JMRI·Girolamo CrisiFrancesca Bozzetti
May 10, 2017·Neurosurgery·Javier E Villanueva-MeyerSoonmee Cha
Dec 19, 2018·Journal of Magnetic Resonance Imaging : JMRI·Bart R J van DijkenAnouk van der Hoorn
Oct 5, 2019·Radiologic Clinics of North America·Sara B StraussGloria C Chiang
Nov 30, 2020·Drug Discovery Today·Rebecca KassubekHeiko G Niessen
May 1, 2021·Radiologic Clinics of North America·Austin TrinhMichael Iv

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