Quantification of single-breath underestimation of lung volume in emphysema

Respiratory Physiology & Neurobiology
Fulvia MiliteRobert C Basner

Abstract

The extent to which a single breath measurement represents available gas dilutional as well as compressible thoracic volume in emphysema patients has not been quantified. We therefore measured single breath (TLCSB) and rebreathe helium dilution (TLCRB), and plethysmographic lung volume (TLCpleth), in fifty-five outpatients with clinical and radiographic emphysema, and in twenty-one normal controls. Among emphysema patients, TLCSB increasingly underestimated both TLCpleth and TLCRB as FEV1% predicted decreased (p for interaction=0.001 for both) by a mean of 1.7 l for TLCRB (p<0.001) and 2.2l for TLCpleth (p<0.001). In contrast, TLCRB underestimated TLCpleth by a mean of 0.5l (p<0.001) regardless of FEV1% (p for interaction=0.25). TLCSB, TLCRB, and TLCpleth showed strong agreement among normal subjects. We conclude that TLCSB underestimates available gas dilutional and compressible lung volume as physiologic emphysema severity increases. In contrast, TLCRB and TLCpleth show closer agreement which is unaffected by physiologic emphysema severity.

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Citations

Jan 22, 2015·The American Journal of the Medical Sciences·Xian Wen SunWei Wu Deng
Jul 6, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·David A KaminskyDavid G Chapman
May 29, 2012·Respiratory Physiology & Neurobiology·Jeremy A WeingartenRobert C Basner
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Aug 28, 2016·Respiratory Investigation·Paul Enright Md
Jan 30, 2014·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Patrícia Chaves CoertjensSérgio Saldanha Menna Barreto
May 17, 2018·Frontiers in Physiology·Dejan RadovanovicPierachille Santus
Sep 11, 2019·Pediatric Pulmonology·Johanna SivunenAnssi Ra Sovijärvi

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