Quantification of synovitis in the cranio-cervical region: dynamic contrast enhanced and diffusion weighted magnetic resonance imaging in early rheumatoid arthritis--a feasibility follow up study

European Journal of Radiology
M JeromelM Tomšič

Abstract

To test the feasibility of dynamic contrast enhanced (DCEI) and diffusion weighted (DWI) magnetic resonance imaging (MRI) for quantifying synovitis of the cranio-cervical (C-C) region in patients with early rheumatoid arthritis (RA) and neck pain at the beginning and at a six month follow up. 27 patients with duration of RA of less than 24 months and neck pain were studied with standard qualitative MRI evaluation and two quantitative MRI methods (DCEI and DWI) at the level of atlantoaxial joints. Rate of early enhancement (REE), enhancement gradient (Genh) and apparent diffusion coefficient (ADC) were extracted from DCEI and DWI data. MRI was coupled with clinical assessment and radiographic imaging. Using standard qualitative MRI evaluation, unequivocal active synovitis (grade 2 or 3 contrast enhancement) was proved in 16 (59%) patients at baseline and 14 (54%) at follow up. DCEI and DWI measurements confirmed active synovitis in 25 (93%) patients at baseline and 24 (92%) at follow up. Average REE, Genh and ADC values decreased during follow up, however the difference was not statistically significant (p>0.05). Both qualitative and quantitative MRI methods confirmed active inflammatory disease in the C-C region following thera...Continue Reading

References

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Dec 14, 2011·Topics in Magnetic Resonance Imaging : TMRI·Jalal B Andre, Roland Bammer

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Citations

Feb 24, 2015·Diagnostic and Interventional Imaging·B DallaudièreA Larbi
Aug 16, 2016·Clinical Radiology·K Yao, J M Troupis
Jan 18, 2014·Journal of Magnetic Resonance Imaging : JMRI·Zhen LeiTianyu Zou
Oct 14, 2017·Pediatric Rheumatology Online Journal·Alexander SauerHenning Neubauer
Nov 9, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Naohisa HiraharaSatoshi Tokunaga

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