Quantification of tantalum sedimentation rates in liquid embolic agents

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences
J R MasonG Benndorf

Abstract

Background Endovascular treatment (EVT) of brain arteriovenous malformations has evolved from cyanoacrylate derivatives such as N-butyl cyanoacrylate, an adhesive glue, to ethylene vinyl copolymer-based liquid embolics such as Onyx® and SQUID® dissolved in dimethyl sulfoxide. Although these agents offer several advantages, their rapidly decreasing radiopacity, as a result of the sedimentation of tantalum powder, compromises visual control during EVT. This study aims to quantify and compare tantalum sedimentation rates of several liquid embolic agents, and determine their effects on radiopacity. Methods The rate of sedimentation of liquid embolics Onyx 18®, SQUID 12®, and SQUID 18® was measured after preparation by single x-ray exposures for a period of 30 minutes. The signal-to-noise ratios (SNRs) of the suspension of each liquid embolic was calculated at various time points as tantalum settled out of the suspension. Precipitating Hydrophobic Injectable Liquid (PHIL®) was imaged as a control. Results Onyx 18® demonstrated the fastest sedimentation rate of the liquid embolics analyzed and demonstrated a threefold faster drop in SNR compared to SQUID 18® over 30 minutes. Onyx 18® demonstrated a one and a half times faster drop in...Continue Reading

References

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Citations

Dec 21, 2018·Journal of Neurointerventional Surgery·Raoul PopRémy Beaujeux
Aug 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jasmine LordAndrew L Lewis
Dec 21, 2019·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Alessandro PedicelliCesare Colosimo
Nov 21, 2020·AJNR. American Journal of Neuroradiology·N SchmittD F Vollherbst
Sep 27, 2021·Journal of Vascular and Interventional Radiology : JVIR·Richard M BrillWalter Alexander Wohlgemuth

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