Quantification of the curvature and shape of the interventricular septum

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Daniel A Moses, Leon Axel

Abstract

The interventricular septum (IVS) occupies a unique position within the heart, lying between the left (LV) and right (RV) ventricular cavities. Changes in its normal geometry may signify not only abnormalities of the septal myocardium, but also abnormal pressure differences between the LV and RV. Flattening of the IVS has been noted with cross-sectional imaging in association with pulmonary hypertension, but the septal curvature and shape have not previously been measured in three dimensions. This paper describes a method to model the RV surface of the IVS from spatially registered cross-sectional images for measurements of curvature. A smoothing 2D spline surface is constructed through the RV septal surface at regular times during the cardiac cycle, and the principal curvatures, as well as the Gaussian and mean curvatures, shape index, and curvedness, are calculated. Vector and color surface maps and graphs of average curvature and shape indices are constructed. Consistent curvature patterns were observed in four normal subjects. This method of measuring septal geometry can provide potentially useful new information on the effects of RV disease. We examine the problem of describing septal motion, and describe a simple measure ...Continue Reading

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Citations

May 10, 2005·Medical Image Analysis·Leon AxelDaniel Kim
Aug 11, 2010·Human Molecular Genetics·Monir ShababiChristian L Lorson
Feb 17, 2007·Cardiology in Review·Susan M SallachSharon Reimold
Mar 2, 2006·Current Cardiology Reports·Vinay M Pai, Leon Axel
Dec 26, 2007·The American Journal of Cardiology·Florence H SheehanAlan H Stolpen
Nov 16, 2017·The International Journal of Cardiovascular Imaging·Mie KunioElazer R Edelman
Dec 19, 2006·Journal of Magnetic Resonance Imaging : JMRI·Andreas SigfridssonLars Wigström
Apr 11, 2006·Physiological Measurement·T J ClarkE L Bolson
Mar 4, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ying ZhanLu Sun
Aug 11, 2020·PLoS Computational Biology·Maria SalferAntonio Martínez-Sánchez

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