Quantification of the duodenal eosinophil content in adults: a necessary step for an evidence-based diagnosis of duodenal eosinophilia

Alimentary Pharmacology & Therapeutics
R M GentaK Turner

Abstract

The normal content of eosinophils in the adult duodenum remains undefined. Therefore, there is no foundation for evidence-based criteria to diagnose eosinophilic duodenitis. This study aimed at: (1) establishing the range of the eosinophil density in the mucosa of the duodenum of normal adults, and (2) determining the biopsy-based prevalence of isolated eosinophilic duodenitis in a large population of adults. We counted intact eosinophils in three separate high-power fields (hpf area = 0.237 mm2 each) with the highest densities of eosinophils from the duodenal biopsy specimens of 370 consecutive adults (60% women) with no history of small intestinal disease and a normal duodenal histology. From a large database we also extracted patients with a diagnosis of elevated duodenal eosinophilia and reviewed their biopsies and clinical history. The mean eosinophil count for the 370 patients was 8.2 eos/hpf with a standard deviation of ± 6.3. Twenty-seven of the 370 had eosinophil counts outside the 95% range, which was calculated as: mean + 1.96 × SD = 20.4 eos/hpf. In a database of 458 668 adult subjects, 31 patients (6.8/100 000) had elevated duodenal eosinophilia; 21 of these had other gastrointestinal organs involved by eosinophili...Continue Reading

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Citations

Nov 28, 2019·Digestive Diseases and Sciences·Robert D PesekUNKNOWN Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)
Jul 16, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Amnon SonnenbergRobert M Genta
Aug 11, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Susrutha Puthanmadhom NarayananAdil E Bharucha
Apr 13, 2018·Alimentary Pharmacology & Therapeutics·P Singh, D A Leffler
Jul 11, 2018·Virchows Archiv : an International Journal of Pathology·Jorge SilvaJorge Amil Dias
Aug 18, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Craig C ReedEvan S Dellon
May 12, 2021·BMJ Case Reports·Harry Jin, Kellee Slater
Jun 6, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonRobert M Genta
Jul 2, 2021·Digestive Diseases and Sciences·Brent HiramotoIkuo Hirano

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