Quantification of the humoral immune response and hemoplasma blood and tissue loads in cats coinfected with 'Candidatus Mycoplasma haemominutum' and feline leukemia virus

Microbial Pathogenesis
Godelind A Wolf-JäckelRegina Hofmann-Lehmann

Abstract

'Candidatus Mycoplasma haemominutum' (CMhm) is a hemotropic mycoplasma (aka hemoplasma) of domestic cats and wild felids. In a transmission study, we exposed eight specified pathogen-free cats to blood from Iberian lynxes (Lynx pardinus) infected with CMhm. The cats were coinfected with feline leukemia virus (FeLV) from an Iberian lynx or with a prototype FeLV. The goal of the present study was to quantify the humoral immune response to CMhm and to identify potential target tissues and sequestration sites. Antibodies were measured by a recombinant antigen-based enzyme-linked immunosorbent assay, and blood and tissue loads were quantified using real-time PCR. Seven out of eight cats became CMhm-infected; all of these cats seroconverted between 3 and 13 weeks after inoculation. Antibody levels correlated with the CMhm blood loads. The peak CMhm blood loads were inversely correlated with the incubation period. PCR-positive results were found in all 24 tissues tested but not for all samples. Although all tissues were PCR-positive in one cat euthanized ten weeks after infection, many tissues tested negative in six cats euthanized at week 20 after infection. In several cats, the spleen, lung, liver, heart and aorta contained more cop...Continue Reading

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Citations

Mar 6, 2013·New Zealand Veterinary Journal·E Barker, S Tasker
Aug 6, 2010·The Journal of Veterinary Medical Science·Miki TanaharaYasuyuki Endo
Jun 6, 2013·Molecular Biology International·A Katrin Helfer-HungerbuehlerRegina Hofmann-Lehmann
Sep 4, 2013·Veterinary Microbiology·Marilisa NovaccoRegina Hofmann-Lehmann
Aug 4, 2018·Molecular Ecology·Carmit CohenHadas Hawlena
Sep 29, 2020·Transboundary and Emerging Diseases·Paulina Sepúlveda-GarcíaAnanda Müller
Jun 12, 2021·BMC Veterinary Research·Julia StadlerLudwig E Hoelzle

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