PMID: 9525767Apr 3, 1998Paper

Quantification of the passive mechanical properties of the resting platelet

Annals of Biomedical Engineering
J H HagaJ Strony

Abstract

Sudden coronary artery occlusion is one of the leading causes of death. Several in vitro models have been used to study the relationship between hemodynamic forces and platelet function. However, very few in vivo studies exist that fully explore this relationship due to the lack of rheologic data for the platelet. For this purpose, micropipette aspiration techniques were used in the present study to determine the mechanical properties of platelets. The data were analyzed by two mathematical models: (1) an erythrocyte-type membrane model which yielded a platelet shear modulus of 0.03+/-0.01 dyn cm[-1] (mean+/-SD) and a viscous modulus of 0.12+/-0.04 dyn s cm[-1]. (2) An endothelial-type cell model which approximated the platelet Young's modulus to be 1.7+/-0.6 x 10(3) dyn cm(-2) with a viscous modulus of 1.0+/-0.5 x 10(4) dyn s cm(-2). The endothelial-type cell model more accurately describes the mechanics occurring at the micropipette tip and permits more appropriate assumptions to be made in quantifying the rheologic properties of a platelet. Results from this study can be integrated into numerical models of blood flow in stenosed coronary arteries to elucidate the impact of local hemodynamics on platelets and thrombus formati...Continue Reading

Citations

Aug 14, 2010·Biomechanics and Modeling in Mechanobiology·Brianna McGrathMichel R Labrosse
Mar 12, 2008·Annals of Biomedical Engineering·T AlMomaniK B Chandran
Sep 12, 2012·Annals of Biomedical Engineering·Daniel A ReasorCyrus K Aidun
May 23, 2013·Annals of Biomedical Engineering·Joao S SoaresDanny Bluestein
Apr 10, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Nipa A Mody, Michael R King
Nov 10, 2001·Annual Review of Biomedical Engineering·D M Wootton, D N Ku
Jul 16, 2011·Annual Review of Biomedical Engineering·Elisa KonofagouJonathan Vappou
Oct 25, 2012·Biomaterials·Christa L Modery-PawlowskiAnirban Sen Gupta
Mar 29, 2003·Transfusion·Suny ThomasRoger Tran-Son-Tay
Dec 24, 2014·International Journal for Numerical Methods in Biomedical Engineering·Seetha PothapragadaDanny Bluestein
Jul 24, 2015·Annals of Biomedical Engineering·Siu Ling LeungMarvin J Slepian
Feb 3, 2015·Journal of Computational Physics·Peng ZhangDanny Bluestein
Nov 16, 2014·Annals of Biomedical Engineering·Toshihiro OmoriTakami Yamaguchi
Aug 22, 2017·Frontiers in Physiology·Gábor ZávodszkyAlfons Hoekstra
Oct 31, 2019·Cellular and Molecular Bioengineering·Prachi GuptaYuefan Deng
Mar 27, 2020·Research and Practice in Thrombosis and Haemostasis·Laura SachsRaghavendra Palankar
Sep 19, 2018·Biophysical Journal·Hung-Yu ChangGeorge Em Karniadakis
Mar 31, 2021·Biomechanics and Modeling in Mechanobiology·Prachi GuptaYuefan Deng
May 12, 2021·Annals of Biomedical Engineering·Jawaad SheriffDanny Bluestein
Jul 25, 2021·International Journal of Molecular Sciences·Angie De La CruzRolando E Rumbaut

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