Quantification of tissue-engineered trachea performance with computational fluid dynamics

The Laryngoscope
Lauren EichakerTendy Chiang

Abstract

Current techniques for airway characterization include endoscopic or radiographic measurements that produce static, two-dimensional descriptions. As pathology can be multilevel, irregularly shaped, and dynamic, minimal luminal area (MLA) may not provide the most comprehensive description or diagnostic metric. Our aim was to examine the utilization of computational fluid dynamics (CFD) for the purpose of defining airway stenosis using an ovine model of tissue-engineered tracheal graft (TETG) implantation. Animal research model. TETGs were implanted into sheep, and MLA was quantified with imaging and endoscopic measurements. Graft stenosis was managed with endoscopic dilation and stenting when indicated. Geometries of the TETG were reconstructed from three-dimensional fluoroscopic images. CFD simulations were used to calculate peak flow velocity (PFV) and peak wall shear stress (PWSS). These metrics were compared to values derived from a quantitative respiratory symptom score. Elevated PFV and PWSS derived from CFD modeling correlated with increased respiratory symptoms. Immediate pre- and postimplantation CFD metrics were similar, and implanted sheep were asymptomatic. Respiratory symptoms improved with stenting, which maintaine...Continue Reading

References

Apr 15, 2003·Toxicology and Applied Pharmacology·Tsung-Ming ShihJohn H McDonough
May 6, 2004·Archives of Histology and Cytology·Dwi Liliek KusindartaYoshio Yamamoto
Sep 2, 2004·IEEE Transactions on Medical Imaging·Juan R Cebral, Ronald M Summers
Jan 2, 2009·The Laryngoscope·Mihai MihaescuJ Paul Willging
May 22, 2009·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Ching-Long LinEric A Hoffman
Aug 14, 2009·Health and Quality of Life Outcomes·Bruce BarrettMozhdeh Bahrainian
Jul 1, 2009·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Merryn H TawhaiChing-Long Lin
Aug 10, 2012·International Journal of Pediatric Otorhinolaryngology·Olivia Mimouni-BenabuRichard Nicollas
Dec 6, 2012·Experimental Hematology & Oncology·Chien-Yi HoTzu-Ching Shih
Aug 14, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Candice L Bjornson, David W Johnson
Dec 4, 2013·Thoracic Surgery Clinics·Philipp Jungebluth, Paolo Macchiarini
May 29, 2014·Tissue Engineering. Part C, Methods·Hirotsugu KurobeChristopher K Breuer
Nov 11, 2015·Journal of Pediatric Surgery·Elizabeth S ClarkChristopher K Breuer
Nov 20, 2016·International Journal of Pediatric Otorhinolaryngology·Victoria K PepperTendy Chiang
Jan 10, 2017·Journal of Thoracic Disease·Claudia SchweigerMichael J Rutter
Mar 30, 2017·The Laryngoscope·Victoria K PepperTendy Chiang

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Citations

May 30, 2019·International Forum of Allergy & Rhinology·Chengyu LiKai Zhao
Aug 31, 2020·Laryngoscope Investigative Otolaryngology·Weston L NiermeyerTendy Chiang
May 1, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Victoria PepperTendy Chiang

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