PMID: 9194579May 1, 1997Paper

Quantification of vascularity in nodular melanoma and Spitz's nevus

Journal of Cutaneous Pathology
M BinderH Pehamberger

Abstract

Spitz's nevi are acquired benign melanocytic skin tumors. Usually they are differentiated from nodular melanoma by clinical and histopathological criteria. Since Spitz's nevi are one of the most common simulators of nodular melanomas their bizarre histopathology may cause diagnostic confusion and make it difficult to differentiate these two melanocytic tumors. One of the histologic features shared by Spitz's nevus and nodular melanoma is prominent vascularity. The ability of malignant melanoma to induce angiogenesis is well established whereas benign melanocytic tumors do not have a prominent overall vascularity. The purpose of this study was to find out whether the degree of vascularity of nodular melanomas differs significantly from that of benign Spitz's nevi. In this study the number of microvessels and the vessel area were determined in 23 Spitz's nevi and 16 nodular melanomas. The number of microvessels and the vessel area were determined on Ulex Europaeus agglutinin I-stained sections by computer-assisted image analysis. Two methods of measurement were used, namely systematic and selective sampling. Measurement of the whole tumor specimen (systematic sampling) revealed a vessel count of 10.83/field (SD +/-5.97) for Spitz...Continue Reading

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Citations

Feb 10, 2000·The American Journal of Pathology·R FolbergA J Maniotis
Jan 29, 2000·The British Journal of Dermatology·G Fabrizi, G Massi
Dec 17, 1998·The American Journal of Dermatopathology·S F Cramer
Jan 20, 2006·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Markus StückerPeter Altmeyer
Apr 18, 2013·Bulletin of Entomological Research·Siddharth TiwariLukasz L Stelinski

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