Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension

Investigative Ophthalmology & Visual Science
Santosh G K GaddeAbhijit Sinha Roy

Abstract

To evaluate a fully automated local fractal dimension method to quantify vessel density and foveal avascular zone (FAZ) area in optical coherence tomography angiography (OCTA) images. Fifty-two healthy Asian Indian eyes underwent imaging prospectively with OCTA system. Superficial and deep retinal vascular plexus was imaged. Local fractal analysis was applied to the OCTA images. A scan area of 3 × 3 mm was selected in the superficial and deep retinal layers. Foveal avascular zone area and vessel density were quantified in circular and sectoral zones around the fovea. A unique contour map of vessel density and dropout zones was developed to perform regional comparisons. Foveal avascular zone of superficial (0.35 ± 0.013 mm2) and deep (0.49 ± 0.012 mm2) retinal vascular plexus was segmented. The agreement between the manually segmented and local fractal dimension segmented FAZ area was 0.97 (95% confidence interval [CI]: 0.94-0.98) and did not change significantly with age (P = 0.94 and 0.21, respectively). The vessel density was greater in the deep than the superficial retinal vascular plexus (P < 0.0001). When the image was subdivided into sectors around the FAZ, inferior sector had greater vessel density than the others (tempo...Continue Reading

Citations

May 13, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Mayss Al-SheikhSriniVas R Sadda
May 15, 2018·Current Eye Research·Sunee Chansangpetch, Shan C Lin
Dec 3, 2017·Scientific Reports·Ian J C MacCormickGabriela Czanner
Dec 29, 2017·Indian Journal of Ophthalmology·Jyoti MataliaAbhijit Sinha Roy
Jun 30, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Prachi A DaveJay Chhablani
Apr 11, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C LommatzschS Grisanti
Jul 19, 2018·Ophthalmic Surgery, Lasers & Imaging Retina·Neha AnegondiAbhijit Sinha Roy
Oct 4, 2018·Translational Vision Science & Technology·Rachel E LindermanJoseph Carroll
Jan 25, 2018·The British Journal of Ophthalmology·Harpal Singh SandhuAyman El-Baz
Nov 22, 2018·Expert Review of Medical Devices·Malvika AryaNadia K Waheed
May 17, 2018·Translational Stroke Research·Arjang SalehiAndre Obenaus
Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
Jul 28, 2016·The British Journal of Ophthalmology·Mayss Al-SheikhSriniVas R Sadda
Aug 16, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Mayss Al-SheikhSriniVas R Sadda
Jul 14, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Fabio GrizziEgesta Lopci
Dec 20, 2018·Translational Vision Science & Technology·Acner CaminoDavid Huang
Aug 8, 2019·Eye and Vision·Fan TanYingzi Li
Apr 14, 2020·BioMed Research International·Yifan ZhouXiaodong Sun
Jul 25, 2019·Translational Vision Science & Technology·Omer AharonyYair Zimmer
Dec 11, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Viktoria C BrücherMaged Alnawaiseh

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