Quantification of water diffusion and relaxation times of human U87 tumors in a mouse model

NMR in Biomedicine
Yanping SunMark W Kieran

Abstract

Assessing the potential of anti-cancer agents can be greatly facilitated by applying MRI methods to investigations with animal models. Quantitative diffusion imaging, T1, and T2 measurements may offer valuable information for understanding properties of the tumor and for evaluating new therapeutic approaches. The human U87 high-grade glial tumor is widely used for cancer investigations in orthotopic murine models. The physiological features of this model at the cellular and sub-cellular level have not, however, been well characterized by MRI. In this study, we measured the diffusion, T1 and T2 characteristics of water in the human U87 tumor at 8.5 T in an orthotopic murine model in vivo and analyzed their detailed changes in the transition from the tumor core through the tumor periphery, and out to surrounding tissue using custom developed radial profile analysis software. For the tumor bearing mice (n = 10), the mean average apparent diffusion coefficient (ADC) of the tumor core was 1.03 +/- 0.02 ( x 10(-3) mm2/s), while in the contralateral normal brain it was 0.73 +/- 0.03 ( x 10(-3) mm2/s). The mean T1 in tumor was 2.03 +/- 0.08 s and in normal brain tissue was 1.64 +/- 0.06 s. The mean T(2) in tumor was 0.062 +/- 0.002 s a...Continue Reading

Citations

Sep 14, 2010·Medical Physics·Matthew P LarocqueB Gino Fallone
Jul 31, 2008·Journal of Magnetic Resonance Imaging : JMRI·Sylvain MirauxEric Thiaudiere
Apr 21, 2012·Journal of Magnetic Resonance Imaging : JMRI·Mingming ZhuHarlan E Shannon
Oct 22, 2010·NMR in Biomedicine·Irvin TehDavid J Larkman
Sep 12, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anjum Ali Sharief, G Allan Johnson
Apr 25, 2007·NMR in Biomedicine·Stasia A Anderson, Joseph A Frank
Feb 13, 2010·Physics in Medicine and Biology·Matthew P LarocqueB Gino Fallone
Nov 18, 2010·Physics in Medicine and Biology·Viktória PrantnerJukka S Jurvelin
Jan 7, 2015·Cold Spring Harbor Protocols·Yanping Sun, Andrew L Kung

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