Quantification with a dedicated breast PET/CT scanner.

Medical Physics
Spencer L BowenRamsey D Badawi

Abstract

Dedicated breast PET/CT is expected to have utility in local staging, surgical planning, monitoring of therapy response, and detection of residual disease for breast cancer. Quantitative metrics will be integral to several such applications. The authors present a validation of fully 3D data correction schemes for a custom built dedicated breast PET/CT (DbPET/CT) scanner via (18)F-FDG phantom scans. A component-based normalization was implemented, live-time was estimated with a multicomponent model, and a variance reduced randoms estimate was computed from delayed coincidences. Attenuation factors were calculated by using a CT based segmentation scheme while scatter was computed using a Monte Carlo (MC) simulation method. As no performance standard currently exists for breast PET systems, custom performance tests were created based on prior patient imaging results. Count-rate linearity for live-time and randoms corrections was measured with a decay experiment for a solid polyethylene cylinder phantom with an offset line source. A MC simulation was used to validate attenuation correction, a multicompartment phantom with asymmetric activity distribution provided an assessment of scatter correction, and image uniformity after geome...Continue Reading

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Citations

Feb 2, 2018·Medical Physics·Raymond R RaylmanMark Perna
Nov 15, 2017·Journal of Medical Imaging·Chengeng ZengLawrence R MacDonald
Oct 29, 2020·Physics in Medicine and Biology·Srilalan KrishnamoorthySuleman Surti
Mar 27, 2021·Physics in Medicine and Biology·Abhijit J Chaudhari, Ramsey D Badawi
Feb 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David F C HsuCraig S Levin
Jul 6, 2018··Chengeng ZengLawrence MacDonald

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